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1 Pharmacology > Endocrine - Pituitary + Adrenal Disorders > Flashcards

Endocrine - Pituitary + Adrenal Disorders Flashcards

1
Q

Types of Pituitary Disorders

A

1 Growth Hormone [GH] Deficiency
2 Diabetes Insipidus [DI]
3 Adrenal Insufficiency

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2
Q

Growth Hormone[GH]

A
  • released by ANT.pituitary gland

- stim growth of bones + tissues

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3
Q

GH Deficiency

s/s

A

aka dwarfism, or pituitary dwarfism

-short stature w normal body proportions

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4
Q

GH Deficiency

Tx

A

somatropin
soma=body
tropin=growth

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5
Q

somatropin

MOA

A

replacement hormone

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6
Q

somatropin

CI

A
  • severely obese

- sleep apnea

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7
Q

somatropin

indications

A
  • deficiency
  • AIDS wasting
  • cachexia (dramatic loss of skeletal muscle)
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8
Q

*somatropin

A/E

A
  • HYPERglycemia incr blood sugar
  • renal calculi/kidney stones/nephrolatisis
  • —decr UO w norm BUN/Cr - check stones or BPH
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9
Q

somatropin

interactions

A

concurrent corticosteroids can inactivate

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10
Q

*somatropin

admin

A
  • IM or subQ

- reconstitute (roll to mix)

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11
Q

*somatropin

RN/teaching

A
  • adjust insulin
  • monitor flank pain
  • drink plenty of fluid
  • rotate injection sites
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12
Q

Diabetes Insipidus [DI]

A

-excessive urination due to ADH deficiency

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13
Q

Diabetes Insipidus [DI]

Tx

A

vasopressin or desmopressin

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14
Q

vasopressin + desmopressin

MOA

A

hormone replacement

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15
Q

*vasopressin + desmopressin

CI

A
  • CAD
  • MI
  • Angina
  • -monitor EKG
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16
Q

vasopressin + desmopressin

indication

A
  • DI
  • low BP
  • nocturnal enuresis
  • CPR
17
Q

vasopressin + desmopressin

A/E

A
  • constricts coronary arteries
  • water intoxication
  • decr periph circulation
18
Q

*vasopressin + desmopressin

interactions

A

***lithium

19
Q

vasopressin + desmopressin

admin

A
  • subQ + IM
  • intranasal
  • starts w bedtime doses
20
Q

vasopressin + desmopressin

RN/teaching

A

monitor:

  • serum Na
  • I+O
  • urine SG
  • EKG + BP
21
Q

Adrenal insufficiency

aka Addison’s Disease

A

-adrenal cortex doesn’t make enough cortisol (helps respond to stress)

22
Q

Cortisol

A
  • incr blood glucose
  • regulates metab
  • salt water balance
  • memory formation
23
Q

Adrenal insufficiency
aka Addison’s Disease
Tx

A

glucocorticoid (steroid hormones)

24
Q

glucocorticoids

drug names

A

1 hydrocortisone
2 dexamethasone
3 prednisone

25
Q

glucocorticoids
[hydrocortisone, dexamethasone, prednisone]
MOA

A

replacement

26
Q

glucocorticoids
[hydrocortisone, dexamethasone, prednisone]
CI

A

active infections

steroids decr immune system

27
Q

glucocorticoids
[hydrocortisone, dexamethasone, prednisone]
indications

A
  • Addison’s disease
  • tons of inflammatory disorders
  • **allergies (v common)
28
Q

**glucocorticoids
[hydrocortisone, dexamethasone, prednisone]
A/E

A
  • HYPERglycemia
  • decr immune
  • wt gain
  • hypo-K
  • osteoporosis
  • adrenal suppression
  • HTN
  • edema
  • infection
  • Cushing syndrome (too much cortisol)
29
Q

glucocorticoids
[hydrocortisone, dexamethasone, prednisone]
interactions

A

vaccines, diuretics, NSAIDs, APAP, ETOH>GI bleed

30
Q

**glucocorticoids
[hydrocortisone, dexamethasone, prednisone]
admin

A
  • must adjust insulin
  • taper off/don’t stop abruptly
  • prevent infection (stay away fr sick ppl, report cough)
  • take Ca, vit D, wt bearing exercise (4 osteoperosis)
  • monitor for weakness + low BP
  • monitor for tarry stools

med is PO in AM

31
Q

glucocorticoids
[hydrocortisone, dexamethasone, prednisone]
RN/teaching

A
  • times of stress, incr dose
  • must adjust insulin
  • taper off/don’t stop abruptly
  • prevent infection (stay away fr sick ppl, report cough)
  • take Ca, vit D, wt beating exercise (for osteoporosis)
  • monitor for weakness + low BP
  • monitor for tarry stools

1 Pharmacology (33 decks)

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