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1 Pharmacology > Connective Tissue [RA, Gout, OA] > Flashcards

Connective Tissue [RA, Gout, OA] Flashcards

RA, OA, Gout

1
Q

colchinine is for

A

gout/gouty arthritis

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2
Q

colchinine

MOA

A

treats inflammation

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3
Q

**colchinine

Tx

A

for ACUTE ATTACKS

-often along w NSAIDs

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4
Q

colchinine

AE

A
  • GI toxicity
  • NVD
  • rhabdomyolysis
  • thrombocytopenia
  • bone marrow suppression
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5
Q

colchinine

CI

A

I

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6
Q

**colchinine

RN

A

DONT DRINK GRAPEFRUIT JUICE
DO INCR FLUIDS

  • take w food
  • monitor for pink/red urine
  • monitor for muscle pain
  • report bruising or sore throat
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7
Q

CHRONIC gout meds

A

allopurinol
febuxostat
probenecid

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8
Q

allopurinol, febuxostat, probenecid

MOA

A
  • treats hyperURICEMIA

- protects kidneys

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9
Q

*allopurinol, febuxostat, probenecid

Tx

A

CHRONIC GOUT

-before chemo

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10
Q

allopurinol

AE

A
  • hypersensitivity rxn
  • kidney injury
  • hepatitis
  • NV
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11
Q

probenecid

AE

A
  • renal calculi
  • NV
  • reaction
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12
Q

allopurinol

RN/teaching

A

patient may experience increase attacks during 1st month

-notify physician

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13
Q

probenecid

RN/teaching

A

dont take ASA
dont take w/in 3 weeks of acute attack
take med w meals

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14
Q

*allopurinol, febuxostat, probenecid

RN/teaching

A

AVOID HIGH PURINE FOODS [ETOH, red meats]

allopurinol: may experience increase attacks during 1st month
- notify physician

probenecid: DONT take w ASA, DONT take w/in 3 weeks of acute attack, DO take w meals

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15
Q

fibromyalgia

drugs

A

duloxetine, pregabalin, gabapentin

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16
Q

duloxetine, pregabalin, gabapentin

MOA

A

INCR GABA (inhibitory neurotransmitter)

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17
Q

***duloxetine, pregabalin, gabapentin

Tx

A

fibromyalgia
PERIPHERAL NEUROPATHY
Psych

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18
Q

duloxetine, pregabalin, gabapentin

AE

A
  • drowsiness,
  • dizzy,
  • serotonin syndrome,
  • WD,
  • sex dysfunction,
  • anorgasmic,
  • anorexia

pregabalin, gabapentin: DROWSINESS, dizzy, consti[ation, ab pain, wt gain, angioedema, rhabdo, ED

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19
Q

pregabalin, gabapentin

AE

A
  • DROWSINESS
  • dizzy
  • constipation
  • ab pain
  • wt gain
  • angioedema
  • rhabdo
  • ED
20
Q

duloxetine, pregabalin, gabapentin

CI

A

SNRI - MAO/I

caution w SSRIs

21
Q

duloxetine, pregabalin, gabapentin

RN

A
  • SNRI- monitor for suicidal ideation

- taper off

22
Q

DMARDS stands for

A

Disease-modifying antirheumatic drugs

23
Q

DMARDS

Tx

A

**rheumatoid arthritis

other uses: chemo + transplants

24
Q

most DMARDs takes ___ to start working

A

3-6wk

25
Q

DMARD I

drugs

A
  • methotrexate [MTX]
  • hydroxychloroquine

sulfasalazine
minocycline

26
Q

methotrexate [MTX]

A
  • immunosuppressant
  • for RA [DMARD I]
  • 1st line med
27
Q

methotrexate [MTX]

AE

A
  • HEPATIC FIBROSIS (NO ETOH!!!)
  • bone marros suppression
  • category X
  • stomatitis
  • oral/GI ulcers
  • mild alopecia
28
Q

if rheumatoid arthritis patient is taking MTX and is experiencing mild alopecia, you can give them ____

A

folic acid supplements

29
Q

methotrexate [MTX]

RN/teaching

A
  • takes 8 wks to work
  • bloodwork Qmonthly
  • leucovorin
  • drink 2L water per day
30
Q

hydroxychloroquine

A

anti-malarial

-for RA [DMARD I]

31
Q

hydroxychloroquine

AE

A

blindness

photosensitivity

32
Q

hydroxychloroquine

PT

A

baseline eye exam then Q6mo

33
Q

sulfasalazine

A

anti-inflammatory

-for RA [DMARD I]

34
Q

sulfasalazine

AE

A

bone marrow suppression

hepatotoxic

35
Q

sulfasalazine

CI

A

sulfa allergy

36
Q

minocycline

A

tetracycline

-for RA [DMARD I]

37
Q

types of DMARDS

A

DMARD I - nonBIOLOGIC
DMARD II - BIOLOGIC
DMARD III

38
Q

DMARD II

drugs

A 
1 adalimumab
2 etanercept
3 infliximab
4 rituximab
5 IL-1vanakinra, IL-2
39
Q

adalimumab, etanercept, infliximab

A

TNF antagonist

-for RA [DMARD II]

40
Q

adalimumab, etanercept, infliximab

AE

A
  • pancytopenia
  • HF
  • SJS
  • anaphylaxis
  • infection
  • CA
  • TB reactivation
41
Q

adalimumab, etanercept, infliximab

RN/teaching

A

-need TB test prior bc TB reactivation
infliximab is IV - sharp teaching
adalimumab is SQ

42
Q

rituximab

A

B lympocyte depletor

-for RA [DMARD II]

43
Q

DMARD III drug

A

cyclosporine

44
Q

cyclosporine

A 
immunosuppressant 
-for RA [DMARD III]
*used as last resort bc big toxicities
-frequently used in transplant patients
***EYEDROPS FOR MORE TEARS
CATEGORY X!!!
45
Q

cyclosporine

AE

A 
NEPHROTOXIC
HEPATOTOXIC
GINGIVAL HYPERPLASIA
hirsutism
CATEGORY X!!!!
46
Q

cyclosporine

CI

A

category X
no grapefruit juice
no recent live vaccines

47
Q

DMARDs are often paired with…

A

NSAIDs + steroids bc DMARD’s long onset

also given folic acid + leucovorin prophylactically

1 Pharmacology (33 decks)

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