mech of breathing Flashcards
collapsing tendancy
elasticity of ct (1/3) and all Surface tension (2/3)
surface tension
electrostatic forces in water, water molecules at surface pull down only, contract
ST in alveoli
spherical, ST pulls inward causing interior pressure.
alveolar pressure varies with what?
size! smaller require greater P to keep open
surfactant
lipid plus protein, type II cells, allows ST to vary between alveoli, so one pressure can keep them all open
compliance
change in volume with change in transmural P, stiffness of wall dictates change in volume.
compliance is low at
max volume, max stretch.
hysteresissi
complains in is different from compliance out (out requires less pressure).
saline vs water and compliance
saline has no hysteresis- no ST, more compliance
diseases that reduce complaince
fibrosis
diseases that increase compliance
emphysema
how can the lungs inflate
positive or negative pressure
airway R measure
FEV1/FVC (obstructive less than .7)
Ptm
Palv-Pip, keeps lungs expanded, usually around 4
solubility in plasma
proportional to partial pressure