COPD

Question 1

COPD definition

Answer 1

persistent airflow lim/resp symptoms, airway or all abnormal, chronic inflam» structural changes

Question 2

emphysema def

Answer 2

permanent distal obstruction/destruction and enlargement of airspace, no fibrosis

Question 3

chronic bronchitis

Answer 3

excess mucus, cough/sputem for 3 month/2 + year, airflow obstruction, rule out chronic cough, reversible early

Question 4

RISK FACOTRS

Answer 4

TOBACCO

Question 5

host factors

Answer 5

BHR, BDP, genetic, maternal smoke, child asthma

Question 6

mech of copd

Answer 6

chronic inflam, imbalance of elastase/anti elastase, oxidative stress

Question 7

Clin presentation

Answer 7

dysnnea/tachy, wheeze, increased expiration, cough/sputem, WL, hoover, TA paradox

Question 8

small airway obstruction

Answer 8

more goblet cells, less elastase, more fibrosis, thick airway, less max exp flow

Question 9

less expiratory flow

Answer 9

less recoil, more airway R, less radial traction

Question 10

hyperinflation

Answer 10

elastic increase WOB, air trap, exp issue but feels hared to INSPIRE

Question 11

hypoxemia cause

Answer 11

usually V/Q, periferal airway destruction, more headspace.