Abnormal gas exchange Flashcards
causes of hypoxemia
V/q mismatch, shunt, diffusion abnormality, hypoventilation, low FiO2
v/q
most common. low PaO2 (severe less than 60)
shunt
wide gradient, no change on Pa02 with support
diffusion abnormailty
usually only present WITH EXERCISE.
hypoventilation
narcotics!! high paCo2, may improve with increased Fio2
low Fio2
fire/alt
which hypoxemia causes have wide gradient
v/q, shunt, diffusion
which hypoxemia causes have no gradient
hypovent and low FiO2
PiO =
FiO2(PB-PH20)
PA02=
FiO2(PB-PH20)-
PAO2-PaO2
FiO2(Pb-Ph2o)- (Pao2+PaCo2/r)
CaO2=
1.34(Hgb)(Sao2)+.003(PaO2)
normal carried oxygen
21.2
normal gradient
0-10
what is the biggest determinant of carried oxygen
hemoglobin
hyperventilation effects
mostly more PaCo2, not a huge effect on oxygen
response to V/q mismatch
hypoxic vasoconstriction
PaCo2 normal value
normal 35-45
hypercapnia def
PaCo2>45
causes of hypercapnia
fever, thyroid, catabolic state, overfeeding, but also ventilation or dead space problem!!
effect of increased minute vent on PaCo2
decrease