me again, get studying these pls x Flashcards
Complications of pneumonia
PEASAP Pneumothorax Empyema Abscess Septicaemia AF Post-infective bronchiectasis
Investigation of empyema
Thoracentesis and pleural fluid analysis
CURB65 0-1
Home with amoxcillin/macrolide for 5 days
CURB65 2
Hospital with dual antibiotic therapy amoxicillin and macrolide 7-10 days
CURB65 3+
Hospital/ITU with dual antibiotic therapy macrolide and co-amoxiclav/ceftriaxone/tazocin
U of CURB65
Blood urea nitrogen over 7mmol/l
R of CURB65
RR over 30
B of CURB65
Less than 90/60
Acute pneumonia investigations
ABG, Bloods, Blood Culture, Sputum culture. PCR, Urine antigen and CXR
PUB CABS
PUB CABS
PCR for mycoplasma
Urine antigen for legionella/pneumococcal
Bloods
CXR for lobar, multi-lobar, cavitation, pleural effusion
ABGs
Blood culture
Sputum
Pneumonia
Inflammatory condition of the lungs leading to fluid and blood cells leaking into alveoli, spread leads to consolidation
Legionella pneumonia results
Hyponatraemia, deranged LFTs and legionella antigen in urine
Cavitating pneumonia and red-currant sputum
Klebsiella pneumonia
Pneumocystis jirovecii results
Silver stain showing cysts
Rash associated with mycoplasma pneumoniae
Erythema multiforme
Difference between HAP and CAP
HAP tends to be gram negative such as klebsiella and e. coli
Bilateral cavitating bronchopneumonia
Staphylococcal pneumonia
3 most common pneumonia causes
Strep pneumoniae, Haemophilus influenzae and mycoplasma pnuemoniae
3 most common pneumonia causes
Strep pneumoniae, Haemophilus influenzae and mycoplasma pnuemoniae
Raised ALP suggest
Posthepatic obstruction
Drugs that can cause haemolysis
Anti-malarials
Gilberts syndrome
Causes jaundice you don’t need to treat, liver functions well but bilirubin is building up. Decreased activity of glucuronyl transferase
Carcinoid syndrome
Symptoms someone with neuroendocrine tumours may experience
Level of plasma bilirubin that may lead to visible jaundice
35 micromol/l
Gilbert’s syndrome pattern of inheritance
Autosomal recessive
Urine urobilinogen absent
post-hepatic jaundice
Blood bilirubin raised
Prehepatic jaundice
Urine bilirubin absent
Prehepatic jaundice
H pylori eradication trio
Amoxicillin, clarithromycin and PPI
H pylori eradication trio in penicillin allergy
Metronidazole, clarithromycin and PPI
Urine in prehepatic jaundice
Absent bilirubin and increased urobilinogen
Urine in posthepatic jaundice
Bilirubin present and urobilinogen decreased
Urine in hepatic jaundice
Bilirubin present and urobilinogen increased
Pale stools and dark urine
Cholestasis - large amounts of bilirubin entering circulation and not gut
Diagnostic markers for acute pancreatitis
serum amylase and lipase
Chylomicrons
Carry triglycerides in lymph
Chole cysto kinin
bile sac move
Simulates CCK action
Fatty acids in chyme
Metclopramide
Dopamine antagonist that relaxes LOS and increases motility
Enterochromaffin-like cells
Release histamine when stimulated by gastrin
Atropine
Antagonist of muscarinic receptors and blocks action of Ach
Side effects of SAMAs
Constipation, dizziness, confusion, hallucinations, blurred vision, dry eyes, tachycardia, urinary retention etc
BLIND AS A BAT, DRY AS A BONE, FULL AS A FLASK, HOT AS A HARE, MAD AS A HATTER
Methylxanthines
Inhibit phophodiesterase and block adenosine receptors
Treatment for theophylline toxicity
Activated charcoal and haemodialysis
pus and red inflammation cause by antibiotics
pseudomembranous colitis
red inflammation, fewer inflammatory cells and crypt irregularity caused by poor perfusion
ischaemic colitis
normal endoscopy, thick basement membrane >2-3microns, patchy, watery diarrhoea
collagenous colitis
surface epithelial injury, prominent lymphocytic infiltration and increased lamina prioria mononuclear cells
lymphocytic colitis
collagenous colitis
thickened sub epithelial collagen layer adjacent to basal membrane
type 1 respiratory failure
low oxygen
type 2 respiratory failure
low oxygen high co2
pulmonary fibrosis and lung compliance
decreases lung compliance
tb hypersensitivity type
type IV
TB immune mediated
T-cell mediated
troponin regulates calcium dependent contraction in which types of muscle
skeletal and cardiac
what regulates calcium dependent contraction in most smooth muscles? i
calmodulin
first line coeliac investigation
tTGA
goblet cells in crohns
increased
goblet cells in UC
decreased