MCB Lecture 23 Cancer Flashcards
What are the Big 5 cancers?
Prostate Bowel Breast Skin melanoma Lung
What are the cancer trends in Australia currently?
For the past 20 years, incidence has increased, but the rate has stayed roughly constant
How many deaths per year do the Big 5 represent collectively?
40,000
Has there been any improvement in the cancer incidence rate in Australia?
Yes in some cancers there has been some improvement in morbidity
However, in pancreatic and lung, there has been little to no improvement
What does the term cancer refer to?
Cancer is a generic term for a collection of generic terms
What are the four general types of cancer?
- Carcinoma: cancer of epithelial cells
- Sarcoma : cancer of connective tissue
- Lymphoma: cancer of lymphatic system
- Leukaemia: cancer of blood cells
What are sarcomas?
Cancers of connective tissue
What are carcinomas?
Cancer of epithelial cells
What are leukaemias?
Cancers of blood cells
What are lymphomas?
Cancer of the lymphatic system
What is the relationship between cancer incidence and age?
As age increases, cancer incidence increases
Describe delayed onset
Cancer onset will be a number of years after the exposure to the carcinogen
What are the two types of tumours?
Benign and malignant
What is a benign tumour?
Give an example
Benign tumours do not invade healthy tissues and cause spread of cancerous cells
Cannot create new tumours
Eg. Freckles and moles
What is a malignant tumour?
These tumours can invade healthy tissues, metastasise and cause more tumours
What is metastasis?
This is when cancerous cells are mobile. They move from one area to another.
This may be from the origin to elsewhere, or not
What is the name for the process where a normal cell becomes cancerous?
How does this occur?
Malignant transformation
This occurs when there is a build up of mutations, eventually leading to a cell that has uncontrolled cell division etc.
What is apoptosis?
Programmed cell death
What is senescence?
When a cell is still alive, but is not still growing
What are the two main pathways to tumourigenesis?
- Activation of tumour promoting
2. Deactivation of tumour suppressing
Give a general description of the tumour promoting pathway
Mutation relating to a proto-oncogene
Proto oncogene becomes an oncogene –> increase is cell proliferation