Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

PHRM 825 > Management of Nausea and Vomiting > Flashcards

Management of Nausea and Vomiting Flashcards

1
Q

Symptoms associated with nausea and vomiting

A
  • pallor
  • tachycardia
  • diaphoresis (sweating)
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q
  • nausea occurs in ___ % of pregant women
  • begins ___ - ___ week after last menstrual period
  • usually resolves by ___ week
A
  • 80%
  • 4th-7th
  • 20th
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

T or F: anti-neoplastic drugs rarely cause N/V

A

False; anti-cancer drugs cause N/V

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

If N/V is associated with chest pain, theres a good chance it is a ___

A

myocardial infarctions

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

drug therapy

antihistamines and anticholinergics (3)
MOA: blocks receptors in CTZ/NTS

A
  • meclizine
  • dimenhydrinate
  • scopolamine
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

antihistamines and anticholinergics SE

A

Drowsiness, Sedation, Dry mouth, Constipation; burred vision

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

Phenothiazines (2)
MOA: ___ receptor inhibition in CTZ

A
  • Prochlorperazine
  • Promethazine
  • dopamie
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

Phenothiazines SE

A

Dizziness; sedation; dry mouth; EPS; hypotension

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

Serotonin Antagonists (4)
MOA: serotonin inhibition at CTZ, VC, and GI Tract

A
  • ondansetron
  • granisetron
  • palonosetron
  • dolasetron
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

serotonin antagonists SE

A

Mild HA; Dizziness; Fatigue; Constipation; Recent concern about QT prolongation

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

Neurokinin-1 Antagonists (3)
MOA: ___ receptor inhibition at CTZ, VC, and GI tract

A
  • Aprepitant
  • Fosaprepitant
  • Rolapitant
  • neurokinin
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

Neurokinin-1 Antagonists SE

A

fatigue, hiccups, decreased hiccups

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

Buterophynones (2)
MOA: ___ receptor inhibition in CTZ
SE:

A
  • Haloperidol and Droperidol
  • dopamine
  • drowsiness; EPS; EKG
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

Metoclopramide
MOA: ___ receptor inhibtion in CTZ; ___ inhibition at high dose
SE:

give with benadryl

A
  • dopamine
  • serotonin
  • diarrhea, EPS at high dose
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

Cannabinoids (2)
MOA: binds with cannabinoid receptors in brain
SE:

A
  • Dronabinol
  • Nabilone
  • Sedation; dry mouth; euphoria; dysphoria; may stimulate appetite
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

Corticosteroids (1)
MOA: inhibition of ___ input into VC
SE:

A
  • Dexamethasone
  • cortical
  • Potentiates action of other agents
17
Q

Thienobenzodiazepine (1)
MOA: ___ and ___ receptor inhibition in CTZ
SE:

A
  • dopamine and serotonin
  • Drowsiness; constipation; dry mouth
18
Q

which serotonin antagoinst has the longest duration of action?
A) ondansetron
B) granisteron
C) dolasetron
D) palonosetron

A

palonosetron
t 1/2 = 40 hrs

19
Q

what is the peak age range ___ years

A

12-21

20
Q

Treatment of motion sickness

prevention is key
Scopolamine
* apply patch before needed
* duration = ___ hours

A

72 hours

21
Q

treatment of motion sickness

dimenhydrinate 50 mg
“___”
take po ___ min before needed

A

Dramamine
30-60 min

22
Q

treatment of motion sickness

meclizine 25 mg
“ ___ “ and “ ___”
* dramamine less drowsy
* take po ___ min before needed

A
  • Bonine and Zentrip
  • 30-60 min
23
Q

Treatment of NV Secondary to Gastroenteritis or Pain

treat symptoms while treating the ___
* Ondansetron ___ - ___ mg q8-12h prn
* Promethazine ___-___ mg q4-6h prn

A

cause
* 4-8 mg
* 12.5-25 mg

24
Q

T or F: if you are a woman and or a non-smoker you have a lower risk for N/V PONV

A

False; if you are a woman and do not smoke, you have a higher risk

25
Q

Risk Factors for PONV

Intra-operative use of ___ anesthetics
* use of ___
* type of surgery

A

volatile
* nitrous oxide

26
Q

moderate-high PONV
* drug of choice ___ antagonists
* drugs administered at ___ of procedure

A
  • 5-HT3
  • end
27
Q

highest risk PONV
* 5-HT3 + ___ or ___

A
  • metoclopramide
  • aprepitant
28
Q

Treatment of PONV

Aprepitant ( ___ )
* ___ mg PO 1-3 hours before anesthesia
* may be better than ondansetron

A

Emend
40 mg

29
Q

Prevention of CINV

  • 5-HT3 Antagonist ___
  • NK-1 Antagonist ___
  • Corticosteroids ___
  • olanzapine ___
  • lorazepam
A
  • +
  • +/-
  • +/-

PHRM 825 (49 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions