ANS-5 Flashcards
Antimuscarinic agents are selective for ___, ___, and ___ receptors
M1, M2, M3
Antimuscarinic agents have little effect on ___
nicotinic receptors
Antimuscarinic agents are ____ antagonists
competitive
What is the problem with antimuscarinic agents such as Atropine?
lack of selectivity
Only ___ doses of Atropine can cause a partial block (M1) of the CNS
high
What are the 2 general classes of antimuscarinics?
tertiary amines and quarternary amines
antimuscarinic tertiary amines are mainly used on ___ and ___ applications
ocular, CNS
antimuscarinic quarternary amines are mainly used on ___ and ___ applications
GI tract, peripheral
What is this?
Atropine
What is this?
Anisotropine
T or F: Tertiary amines have good access to the CNS
True
Tertiary amines: Belladonna alkaloids (long acting)
Atropine and Scopolamine (Maldemar)
Tertiary amines: short acting derivatives
Homatropine and Tropicamide
Tertiary amines: Antiparkinson use
Benztropine (Cogentin) and Trihexyphenidyl (Artane)
Quaternary amines: Belladonna alkaloid derivatives
Ipratropium (Atrovent) and Tiotropium (Spiriva)
What is this?
Scopolamine (Maldemar)
Atropine and Scopolamine treat ___, ___, and ___
GI conditions, urinary conditions, and motion sickness
Compared to Atropine, Scopolamine has ___ CNS penetration
higher
Scopolamine is more ___philic than Atropine
lipo
Side effects of Scopolamine
dry mouth, blurred vision, and sedation
High doses: confusion and psychosis
Homatropine and Tropicamide are used in optical applications such as ___ and ___ because of the ___ duration of action
cycloplegia, mydriasis, short
Cycloplegia = paralysis of the ciliary muscle of the eye
Homatropine is ___ toxic; Tropicamide has a ___ duration of action
less, shorter
What is this?
Homatropine
What is this?
Tropicamide