Infertility

Question 1

T or F: female inferility is typically caused by tubal and ovulatory factors

Answer 1

True; combined these make up 80% of female infertilty

Question 2

Urine Ovulation Predictor Kits
* detect surge in ___
* test ___ urine
* + indicates ovulation in ___ hours and peak fertility is in ___ days

Answer 2

• LH
• Morning
• 18-36 hours, 1-2 days

Question 3

• Fertile window is how many days?
• Sperm can live up to ___ days
• an egg’s lifespan is ___ hours after ovulation

Answer 3

• 6 days
• 5 days
• 12-24 hours

Question 4

Controlled Ovarian Hyperstimulation (2 aromatase inhibitors)

Answer 4

• Letrozole
• anastrozole

Question 5

Anastrozole (Arimidex) dosing
___ mg po for 5 days
* weak inhibitor of CYP ___, ___, and ___
* avoid use of ___ derivatives and tamoxifene

Answer 5

• 1 mg
• 1A2, 2C8/9, 3A4
• estrogen

Question 6

Gonadotropiins develop multiple follicles by increasing ____
* IM or SC injections

Answer 6

FSH

Combination of FSH and LH or either alone

Question 7

hCG is used to trigger ___
* after gonadotropins and aromatase inhibitors have been tried
* similar structure to ___
* IM or SC

Answer 7

• ovulation
• LH

Question 8

T or F: High dose/multiple dose of clomiphene could increase risk of endometrial cancer

Answer 8

True

Question 9

T or F: fertility treatments do not increase risk of invasive breast, cervical, endometrial and ovarian cancers, thyroid, melanoma and colon cancer

Answer 9

True

Question 10

Indication and Timing of Infertility Evaluation

• under 35 yo, no pregnancy after ___ months
• 35-40 yo, no pregnancy after ___ months
• > 40 yo, no pregnancy after less than ___ months

Answer 10

• 12 months
• 6 months
• 6 months