Long-Term Control Medications in Asthma and COPD - Biologics Flashcards

1
Q

omalizumab brand name

A

Xolair

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2
Q

omalizumab dosage forms

A
  • prefilled syringe
  • vial reconstitution
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3
Q

omalizumab dosing ages

A

≥ 6-11 and adults

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4
Q

what mechanism does omalizumab use?

A

Anti-IgE
inhibit IgE binding to receptors on mast cells and basophils, inhibit mediator release and attenuation of early- and late-phase allergic response

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5
Q

mepolizumab brand name

A

Nucala

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6
Q

mepolizumab dosage forms

A
  • auto-injector
  • vial for reconstitution
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7
Q

mepolizumab dosing ages

A

≥ 6-11 and adults

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8
Q

reslizumab brand name

A

Cinqair

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9
Q

reslizumab doseage forms

A

vial soultion

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10
Q

reslizumab dosing ages

A

adults

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11
Q

benralizumab brand name

A

Fasenra

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12
Q

benralizumab dosage form

A
  • auto-injectior
  • prefilled syringe
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13
Q

benralizumab dosing ages

A

adults

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14
Q

mepolizumab, reslizumab, and benralizumab are all ___.

A

anti-IL5
blocks binding of IL-5 to the alpha chain of the IL-5 receptor complex, which results in reduced production and survival of eosinophils

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15
Q

depilumab brand name

A

Dupixent

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16
Q

dupilumab dosage form

A

injection

17
Q

dupilumab dosing ages

A

adults

18
Q

omalizumab adverse effects

A
  • headache
  • injection site reactions
  • arthralgias
  • thrombocytopenia
  • pharyngitis
  • sinusitis
  • upper respiratory tract infections
19
Q

omalizumab boxed warning

A

anaphylaxis

20
Q

omalizumab clinical pearls:
* do not give more than ___ mg per injection site
* FDA approved for moderate to severe ___ in patients with a positive skin test or reactivity to a ___ and symptoms that are inadequately controlled with ___

A
  • 150 mg
  • asthma, perennial aeroallergen, ICS
21
Q

mepolizumab adverse effects

A
  • headache
  • injection site reactions
  • arthralgias
  • Herpes Zoster infection
22
Q

mepolizumab clinical pearls:
* Precaution: ___
* Available as an in-clinic or at-home injection
* Indicated for add-on maintenance treatment of patients with severe ___ with an ___ phenotype

A
  • anaphylaxis
  • asthma, eosinophilic
23
Q

reslizumab adverse effects

A
  • injection site reactions
  • myalgias
  • increased
    creatinine phosphokinase
24
Q

reslizumab boxed warning

A

anaphylaxis, malignancies

25
Q

reslizumab clinical pearls:
* Indicated for add-on maintenance treatment of patients with ___ asthma with an ___ phenotype

A
  • severe
  • eosinophilic
26
Q

benralizumab adverse effects

A
  • injection site reactions
  • antibody development
  • headache
  • pharyngitis
  • fever
27
Q

benralizumab clinical pearls
* Precaution: ___
* available as an in-clinic or at-home injection
* Indicated for add-on maintenance treatment of
___ asthma in adults and children ≥12 years of age with an ___ phenotype
* Acts on IL-5 ___ while others act on IL-5

A
  • anaphylaxis
  • severe, eosinophilic
  • receptors
28
Q

dupilumab adverse effects

A
  • Injection site reactions
  • antibody development
  • arthralgias
  • conjunctivitis
29
Q

dupilumab clinical pearls
* Precaution: ___
* Available in pre-filled syringe for in-office or at home administration
* Indicated as an add-on maintenance treatment in patients with ___ to ___ asthma aged 12 years and older with an ___ phenotype or
with oral ___ dependent asthma.

A
  • anaphylaxis
  • moderate, severe
  • eosinophilic, corticosteroid
30
Q

what mechanism does dupilumab use?
Anti-___: blocks binding of IL/4 to reduce eosinophil trafficking and ___ reactions while also blocking ___ to reduce mucus secretion and airway remodeling

A
  • IL4/IL13
  • IgE
  • IL-13