Long-Term Control Medications in Asthma and COPD - Biologics Flashcards
omalizumab brand name
Xolair
omalizumab dosage forms
- prefilled syringe
- vial reconstitution
omalizumab dosing ages
≥ 6-11 and adults
what mechanism does omalizumab use?
Anti-IgE
inhibit IgE binding to receptors on mast cells and basophils, inhibit mediator release and attenuation of early- and late-phase allergic response
mepolizumab brand name
Nucala
mepolizumab dosage forms
- auto-injector
- vial for reconstitution
mepolizumab dosing ages
≥ 6-11 and adults
reslizumab brand name
Cinqair
reslizumab doseage forms
vial soultion
reslizumab dosing ages
adults
benralizumab brand name
Fasenra
benralizumab dosage form
- auto-injectior
- prefilled syringe
benralizumab dosing ages
adults
mepolizumab, reslizumab, and benralizumab are all ___.
anti-IL5
blocks binding of IL-5 to the alpha chain of the IL-5 receptor complex, which results in reduced production and survival of eosinophils
depilumab brand name
Dupixent
dupilumab dosage form
injection
dupilumab dosing ages
adults
omalizumab adverse effects
- headache
- injection site reactions
- arthralgias
- thrombocytopenia
- pharyngitis
- sinusitis
- upper respiratory tract infections
omalizumab boxed warning
anaphylaxis
omalizumab clinical pearls:
* do not give more than ___ mg per injection site
* FDA approved for moderate to severe ___ in patients with a positive skin test or reactivity to a ___ and symptoms that are inadequately controlled with ___
- 150 mg
- asthma, perennial aeroallergen, ICS
mepolizumab adverse effects
- headache
- injection site reactions
- arthralgias
- Herpes Zoster infection
mepolizumab clinical pearls:
* Precaution: ___
* Available as an in-clinic or at-home injection
* Indicated for add-on maintenance treatment of patients with severe ___ with an ___ phenotype
- anaphylaxis
- asthma, eosinophilic
reslizumab adverse effects
- injection site reactions
- myalgias
- increased
creatinine phosphokinase
reslizumab boxed warning
anaphylaxis, malignancies
reslizumab clinical pearls:
* Indicated for add-on maintenance treatment of patients with ___ asthma with an ___ phenotype
- severe
- eosinophilic
benralizumab adverse effects
- injection site reactions
- antibody development
- headache
- pharyngitis
- fever
benralizumab clinical pearls
* Precaution: ___
* available as an in-clinic or at-home injection
* Indicated for add-on maintenance treatment of
___ asthma in adults and children ≥12 years of age with an ___ phenotype
* Acts on IL-5 ___ while others act on IL-5
- anaphylaxis
- severe, eosinophilic
- receptors
dupilumab adverse effects
- Injection site reactions
- antibody development
- arthralgias
- conjunctivitis
dupilumab clinical pearls
* Precaution: ___
* Available in pre-filled syringe for in-office or at home administration
* Indicated as an add-on maintenance treatment in patients with ___ to ___ asthma aged 12 years and older with an ___ phenotype or
with oral ___ dependent asthma.
- anaphylaxis
- moderate, severe
- eosinophilic, corticosteroid
what mechanism does dupilumab use?
Anti-___: blocks binding of IL/4 to reduce eosinophil trafficking and ___ reactions while also blocking ___ to reduce mucus secretion and airway remodeling
- IL4/IL13
- IgE
- IL-13
