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PHRM 825 > ANS-1,2 > Flashcards

ANS-1,2 Flashcards

Autonomic Nervous System 1/9/23

1
Q

Which receptors use the Gq pathway?

A

M1, M3, M5, a1

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2
Q

Which receptors use the Gi pathway?

A

M2, M4, a2

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3
Q

Which receptors use the Gs pathway?

A

B1, B2, B3

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4
Q

What receptor is a 5 subunit sodium ion channel

A

Nicotinic

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5
Q

Heart: rate of contraction - adrenergic response and receptor

A

increase rate of contraction, B1>B2

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6
Q

Heart: rate of contraction - cholinergic response and receptor

A

decrease rate of contraction, M2

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7
Q

Heart: force of contraction - adrenergic response and receptor

A

increase force of contraction, B1>B2

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8
Q

Heart: force of contraction - cholinergic response and receptor

A

decrease force of contraction, M2

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9
Q

Arteries - adrenergic response and receptor

A

vasoconstriction, a1

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10
Q

Veins - adrenergic response and receptor

A

vasoconstriction, a1, a2

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11
Q

Blood flow to Skeletal Muscle - adrenergic response and receptor

A

vasodilation, B2

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12
Q

Endothelium - cholinergic response and receptor

A

release of EDRF (endothelium derived relaxing factor), M3

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13
Q

Lung: bronchiolar smooth muscle - adrenergic response and receptor

A

bronchodilation, B2

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14
Q

Lung: bronchiolar smooth muscle - cholinergic response and receptor

A

bronchoconstriction, M2, M3

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15
Q

Genitourinary Smooth Muscle: Bladder Wall - adrenergic response and receptor

A

relaxation, B3

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16
Q

Genitourinary Smooth Muscle: Bladder Wall - cholinergic response and receptor

A

contraction, M3

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17
Q

Genitourinary Smooth Muscle: Ureter - adrenergic response and receptor

A

contraction, a1

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18
Q

Genitourinary Smooth Muscle: Ureter - cholinergic response and receptor

A

relaxation, M3

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19
Q

Genitourinary Smooth Muscle: Sphincter - adrenergic response and receptor

A

contraction, a1

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20
Q

Genitourinary Smooth Muscle: Sphincter - cholinergic response and receptor

A

relaxation, M3

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21
Q

Genitourinary Smooth Muscle: Uterus (pregnant) - adrenergic response and receptor

A

relaxation (B2) & contraction (a1)

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22
Q

Genitourinary Smooth Muscle: Uterus (pregnant) - cholinergic response and receptor

A

variable, M3

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23
Q

Genitourinary Smooth Muscle: Penis/Vas Deferens - adrenergic response and receptor

A

ejaculation, a1

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24
Q

Genitourinary Smooth Muscle: Penis/Vas Deferens - cholinergic response and receptor

A

erection, M3

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25
Q

Skin: Hair follicles - adrenergic response and receptor

A

contraction, a1

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26
Q

Skin: smooth muscle -adrenergic response and receptor

A

piloerection, a1 (goosebumps)

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27
Q

Sweat Glands: thermoregulation - adrenergic response and receptor

A

increased secretion, M3 (weird exception)

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28
Q

Sweat Glands: Apocrine (stress) - adrenergic response and receptor

A

increased secretion, a1 (NE is neurotransmitter) (nauuuurrrr my hands are sweaty)

29
Q

GI Tract: salivary glands - adrenergic response and receptor

A

increased secretion, a1

30
Q

GI Tract: salivary glands - cholinergic response and receptor

A

increased secretion, M3

31
Q

GI Tract: Smooth Muscles: Walls - adrenergic response and receptor

A

relaxation, a2, B2 (no need for digestion)

32
Q

GI Tract: Smooth Muscles: Walls - cholinergic response and receptor

A

contraction, M3 (rest and digest)

33
Q

GI Tract: Smooth Muscles: Sphincters - adrenergic response and receptor

A

contraction, a1

34
Q

GI Tract: Smooth Muscles: Sphincters - cholinergic response and receptor

A

relaxation, M3

35
Q

GI Tract: Secretion - adrenergic response and receptor

A

decreased secretion, a2 (don’t need digestive juice)

36
Q

GI Tract: Secretion - cholinergic response and receptor

A

increased secretion, M3 (need digestive juice)

37
Q

Liver - adrenergic response and receptor

A

glycogenolysis and gluconeogenesis, a1, B2

38
Q

Fat Cells - adrenergic response and receptor

A

lipolysis, a1, B1, B2, B3

39
Q

Kidney - adrenergic response and receptor

A

increase renin secretion, B1

40
Q

Pancreas - adrenergic response and receptor

A

decrease insulin, a2

41
Q

Eye: Iris: Radial Muscle - adrenergic response and receptor

A

contraction, a1 (mydrasis=pupil dilation)

42
Q

Eye: Iris: Circular Muscle - cholinergic response and receptor

A

contraction, M3 (miosis=pupil constriction)

43
Q

Eye: Ciliary Muscle - adrenergic response and receptor

A

relaxation, B2 (relaxing ciliary muscle = closing drainage = more intraocular pressure)

44
Q

Eye: Ciliary Muscle - cholinergic response and receptor

A

contraction, M3 (contracting ciliary muscle = opening drain = less intraocular pressure)

45
Q

Eye: Ciliary Epithelium - adrenergic response and receptor

A

increased secretion, B2 (makes more aq goo)

46
Q

Eye: Lacrimal glands - adrenergic response and receptor

A

mucus and enzymes, a1

47
Q

Eye: Lacrimal glands - cholinergic response and receptor

A

watery tears, M3

48
Q

SNS and PSNS typically oppose each other, EXCEPT when it comes to _________

A

male sex organs
SNS - ejaculation, a1
PSNS - erection, M3

49
Q

______ and ______ are controlled by SNS only

A

arteries and veins

50
Q

Pilocaprine Mechanism

A

M3 agonist, contracts ciliary muscle and allows for drainage (decreases intraocular pressure)

51
Q

Brimonidine Mechanism

A

a2 agonist, ciliary body inhibits production of aq goo and increase drainage (decreases intraocular pressure)

52
Q

Timolol Mechanism

A

B antagonist, inhibits secretion of aq goo from ciliary epithelium (decreases intraocular pressure)

53
Q

Latanaprost Mechanism

A

prostaglandin PGF2 analog, increase drainage of aq goo (decreases intraocular pressure)

54
Q

What is this?

55
Q

What is this?

56
Q

What is this?

57
Q

What is this?

A

Norepinephrine

58
Q

What is this?

A

Epinephrine

59
Q

preganglionic neurons in the PSNS are short or long?

60
Q

preganglionic neurons in the SNS are short or long?

61
Q

Transmitter in all PSNS
postganglionic neurons is

62
Q

Transmitter in most SNS
postganglionic neurons is

63
Q

In addition to NE, the SNS also utilizes which neurotransmitters?

A

ACh (sweat glands), Epinephrine (adrenal
medulla), Dopamine (renal
vasculature)

64
Q

Primary transmitter of all preganglionic neurons is

65
Q

SNS Exception - Sweat: transmitter responsible for nervous sweaty palms

66
Q

SNS Exception - Sweat: transmitter responsible for thermoregulation (cooling sweat)

67
Q

SNS Exception: Adrenal - Preganglionic neurons synapse directly on to ______

A

the adrenal gland (no postganglion)

68
Q

SNS Exception: Adrenal - the adrenal glands release _______ into the systemic circulation

A

Epinephrine

69
Q

SNS Exception: Kidneys - affected by ______ which is locally synthesized (not ANS)

PHRM 825 (49 decks)

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