Magor-6b

Question 1

What prevents perforin released by NK cells from punching holes in NK cell membrane?

Answer 1

NK cell membrane is covered by protective protein preventing perforin damage

Question 2

ILC meaning

Answer 2

innate lymphoid cell

Question 3

What lineage is ILC?

Answer 3

innate

Question 4

What progenitor is ILC from?

Answer 4

lymphoid

Question 5

ILCs are analogs of?

Answer 5

Th subsets

Question 6

Difference between ILC and Th

Answer 6

ILCs have no TCR

Question 7

Similarities between ILCs and Th (x3)

Answer 7

• secrete similar cytokines
• mediate similar outcomes
• regulated by common TFs

Question 8

What is IL-17 for?

Answer 8

inflammation and antiviral

Question 9

What is IFN-gamma for?

Answer 9

antiviral

Question 10

amphiregulin

Answer 10

promotes healing of epithelial wounds by promoting growth of epithelial cells and fibroblasts

Question 11

What receptors do ILCs use?

Answer 11

PRRs

Question 12

What does Kd represent?

Answer 12

• dissociation constant

- measure of ligand’s ability to dissociate from receptor

Question 13

The higher the Kd, the _____ the bond

Answer 13

weaker

Question 14

What is another way to envision Kd (in terms of number of ligands)?

Answer 14

Kd = number of ligands (in moles) need o be present in solution to keep 50% of receptors bound

Question 15

What determines the fate of a TH precursor?

Answer 15

signals they receive

Question 16

2 things that help direct histone modification and methylation of CpGs?

Answer 16

• TFs

- long non-coding DNA

Question 17

If cytosines get methylated, it can __ ___ binds DNA

Answer 17

no longer

Question 18

Can epigenetic changes to genome be reversed?

Answer 18

Yes

Question 19

MZ B cells (what is MZ?)

Answer 19

Marginal zone

Question 20

2 types of innate B cells

Answer 20

• MZ B cells

- B1 B cells

Question 21

Where are MZ B cells found?

Answer 21

splenic marginal zones

Question 22

Where are B1 B cells found?

Answer 22

circulation; mostly in peritoneal cavity

Question 23

What is the characteristic of the Ab that innate B cells have?

Answer 23

they are invariant

Question 24

What natural Ab do innate B cells secrete?

Answer 24

IgM

Question 25

What are innate B cell’s Ab specific for?

Answer 25

microbial carbohydrates

Question 26

Innate B1 B cells are _____ and ____ exhibit a memory response

Answer 26

self-renewing, don’t