Magor-6b Flashcards
What prevents perforin released by NK cells from punching holes in NK cell membrane?
NK cell membrane is covered by protective protein preventing perforin damage
ILC meaning
innate lymphoid cell
What lineage is ILC?
innate
What progenitor is ILC from?
lymphoid
ILCs are analogs of?
Th subsets
Difference between ILC and Th
ILCs have no TCR
Similarities between ILCs and Th (x3)
- secrete similar cytokines
- mediate similar outcomes
- regulated by common TFs
What is IL-17 for?
inflammation and antiviral
What is IFN-gamma for?
antiviral
amphiregulin
promotes healing of epithelial wounds by promoting growth of epithelial cells and fibroblasts
What receptors do ILCs use?
PRRs
What does Kd represent?
- dissociation constant
- measure of ligand’s ability to dissociate from receptor
The higher the Kd, the _____ the bond
weaker
What is another way to envision Kd (in terms of number of ligands)?
Kd = number of ligands (in moles) need o be present in solution to keep 50% of receptors bound
What determines the fate of a TH precursor?
signals they receive
2 things that help direct histone modification and methylation of CpGs?
- TFs
- long non-coding DNA
If cytosines get methylated, it can __ ___ binds DNA
no longer
Can epigenetic changes to genome be reversed?
Yes
MZ B cells (what is MZ?)
Marginal zone
2 types of innate B cells
- MZ B cells
- B1 B cells
Where are MZ B cells found?
splenic marginal zones
Where are B1 B cells found?
circulation; mostly in peritoneal cavity
What is the characteristic of the Ab that innate B cells have?
they are invariant
What natural Ab do innate B cells secrete?
IgM
What are innate B cell’s Ab specific for?
microbial carbohydrates
Innate B1 B cells are _____ and ____ exhibit a memory response
self-renewing, don’t
