Ingham-5: B Cell Development III Flashcards
1
Q
Where can self-reactive lymphocytes be removed?
A
- Primary lymphoid organs
- Periphery
2
Q
Negative selection
A
removal of self-reactive lymphocytes
3
Q
3 ways for negative selection to happen
A
- clonal deletion
- anergy
- receptor editing
4
Q
Clonal Deletion
A
self-reactive cells undergo apoptosis
5
Q
Functional anergy
A
self-reactive cells become non-responsive tp Ag
6
Q
Receptor editing
A
B cell arrests in development and start rearranging light chain again
7
Q
non conventional B cells (x3)
A
- B1 B cells
- Marginal Zone B cell
- IL-10-secreting regulatory B cells
8
Q
What type of Ag do B1 B cells detect?
A
Carbohydrate-based Ag
