Ingham-4: B Cell Development II

Question 1

Why can junctional diversity cause problems?

Answer 1

it can create a stop codon

Question 2

Successful human chain rearrangement results in formation of ____

Answer 2

pre-BCRs

Question 3

What defines a successful heavy chain rearrangement?

Answer 3

When it can pair with a surrogate light chain

Question 4

Which light chain allele goes first?

Answer 4

kappa

Question 5

What stops light chain rearrangement?

Answer 5

signals initiated by BCR

Question 6

Allelic exclusion

Answer 6

functional rearrangement of one heavy/light chain allele prevents functional rearrangements of the other allele

Question 7

Allotype definition

Answer 7

minor sequence differences in heavy/light chain CONSTANT regions (alleles)

Question 8

What are transitional B cells?

Answer 8

immature B cells that are not self-reactive and have left bone marrow

Question 9

Where do transitional cells get their signals to continue development?

Answer 9

spleen

Question 10

What is BAFF?

Answer 10

B cell activating factor

Question 11

Function of BAFF

Answer 11

required for survival and maturation of B cells

Question 12

What organ secretes BAFF?

Answer 12

spleen

Question 13

Immature B cells express what Ig on cell surface?

Answer 13

IgM

Question 14

Immature B cells use what site and where does it splice to in constant region?

Answer 14

• Poly-A site 2

- mew

Question 15

Mature B cells express what Ig on cell surface?

Answer 15

IgM and IgG

Question 16

Mature B cells use what site and where does it splice to in constant region?

Answer 16

• Poly-A site 4 (mostly)
• Sometimes Poly-A site 2
• delta