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IMIN 371 > Magor-1 > Flashcards

Magor-1 Flashcards

1
Q

AMPs

A
  • bind to pathogen and punch holes in their membrane
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2
Q

examples of AMPs

A
  • defensins and histanins
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3
Q

What are the possible innate immune responses?

A
  • AMPs
  • Complement system
  • PRRs
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4
Q

Phagocytes (examples)

A

macrophages, monocytes, DC

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5
Q

Cytokines

A

secreted mediators of immune response

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6
Q

Chemokines

A

soluble proteins that tell cells where to aggregate

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7
Q

Examples of cytokines

A

IL, IFN, TNF, TGF

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8
Q

FACS

A
  • Fluorescence activated cell sorting

- sorts samples based on the fluorescence they emit

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9
Q

Side scatter in FACS

A 
illustrates complexity (granularity) of cells
- more granules = more complex = more scatter
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10
Q

Forward scatter in FACS

A

illustrates size of cell

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11
Q

Which cells are pAPCs?

A

monocytes, macrophages, and DC

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12
Q

What type of cells are the first responders of the immune system?

A

Granulocytes

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13
Q

Function of neutrophil

A
  • inflammation

- anti-microbial

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14
Q

Function of eosinophil

A
  • inflammation

- anti-parasitic

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15
Q

Function of basophil/mast cell

A

anti-parasitic

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16
Q

2 types of progenitors

A

Myeloid and lymphoid

17
Q

What happens in primary lymphoid organs?

A

hematopoiesis

18
Q

Where do B cells complete their development?

A

Peyer’s patch or appendix (not mouse or human)

19
Q

Name the secondary lymphoid organs

A

spleen, intestine, lymph nodes, tonsils

20
Q

MALT

A

Mucosa Associated Lymphoid Tissues

21
Q

BALT

A

Bronchus Associated Lymphoid Tissues

22
Q

What does MALT deal with?

A

pathogens entering mucosa

23
Q

What does BALT deal with?

A

inhaled pathogens

24
Q

What do lymphatics and lymph nodes deal with?

A

any pathogen that succeeded entering the tissue

25
Q

What does the spleen deal with?

A

any pathogen that has entered the blood vasculature (systemic infection)

26
Q

Where does the blood-capillary network begin?

A

Right under epithelial cells

27
Q

How does lymph travel?

A

interstitial fluids –> capillaries –> lymph nodes –> lymph ducts –> thoracic duct –> jugular and subclavian vein

28
Q

Where in the spleen do antigens detected in blood go to?

A

PALS (periarteriolar lymphoid sheath)

29
Q

What are M-cells?

A

specialized endocytic epithelial cells that take up gut Ag and transport it to B-cells that will colonize Peyer’s patch

30
Q

GALT

A

Gut Associated Lymphoid Tissues

31
Q

T/F: All organisms have innate immunity

A

True

32
Q

What organisms have B/T cell adaptive immunity?

A

Vertebrates

33
Q

What is a plasma cell?

A

A fully differentiated B cell producing 1 type of Ab

IMIN 371 (18 decks)

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