Magor-1 Flashcards
AMPs
- bind to pathogen and punch holes in their membrane
examples of AMPs
- defensins and histanins
What are the possible innate immune responses?
- AMPs
- Complement system
- PRRs
Phagocytes (examples)
macrophages, monocytes, DC
Cytokines
secreted mediators of immune response
Chemokines
soluble proteins that tell cells where to aggregate
Examples of cytokines
IL, IFN, TNF, TGF
FACS
- Fluorescence activated cell sorting
- sorts samples based on the fluorescence they emit
Side scatter in FACS
illustrates complexity (granularity) of cells - more granules = more complex = more scatter
Forward scatter in FACS
illustrates size of cell
Which cells are pAPCs?
monocytes, macrophages, and DC
What type of cells are the first responders of the immune system?
Granulocytes
Function of neutrophil
- inflammation
- anti-microbial
Function of eosinophil
- inflammation
- anti-parasitic
Function of basophil/mast cell
anti-parasitic
2 types of progenitors
Myeloid and lymphoid
What happens in primary lymphoid organs?
hematopoiesis
Where do B cells complete their development?
Peyer’s patch or appendix (not mouse or human)
Name the secondary lymphoid organs
spleen, intestine, lymph nodes, tonsils
MALT
Mucosa Associated Lymphoid Tissues
BALT
Bronchus Associated Lymphoid Tissues
What does MALT deal with?
pathogens entering mucosa
What does BALT deal with?
inhaled pathogens
What do lymphatics and lymph nodes deal with?
any pathogen that succeeded entering the tissue
What does the spleen deal with?
any pathogen that has entered the blood vasculature (systemic infection)
Where does the blood-capillary network begin?
Right under epithelial cells
How does lymph travel?
interstitial fluids –> capillaries –> lymph nodes –> lymph ducts –> thoracic duct –> jugular and subclavian vein
Where in the spleen do antigens detected in blood go to?
PALS (periarteriolar lymphoid sheath)
What are M-cells?
specialized endocytic epithelial cells that take up gut Ag and transport it to B-cells that will colonize Peyer’s patch
GALT
Gut Associated Lymphoid Tissues
T/F: All organisms have innate immunity
True
What organisms have B/T cell adaptive immunity?
Vertebrates
What is a plasma cell?
A fully differentiated B cell producing 1 type of Ab
