Magor-4

Question 1

4 functions of complement

Answer 1

• lysis
• opsonization
• activate inflammatory response
• homeostasis

Question 2

When are complement proteins upregulated?

Answer 2

during acute phase responses

Question 3

What acute phase responses upregulate complement?

Answer 3

• CRP and MBL activation of complement

Question 4

3 methods of detecting pathogen by complement

Answer 4

• classical
• lectin
• alternative

Question 5

What does classical pathway recognize?

Answer 5

anything but self

Question 6

What does lectin pathway recognize?

Answer 6

not self pattern

Question 7

What does alternative pathway recognize?

Answer 7

missing self

Question 8

What molecules help initiate MAC?

Answer 8

• C5b binding to C6 and C7

Question 9

Function of MAC

Answer 9

• membrane attack complex

- punch holes in bacterial membrane –> lysis

Question 10

What Ig is good for CQq binding?

Answer 10

IgM

Question 11

What C molecules are anaphylatoxins?

Answer 11

C3a, C4a, and C5a

Question 12

General function for anaphylatoxins

Answer 12

inflammatory molecules

Question 13

What C molecule facilitates local inflammation for all 3 pathways?

Answer 13

C3a and C5a

Question 14

What C molecule facilitates opsonization for all 3 pathways?

Answer 14

C3b

Question 15

How are Ig-Ag immune complexes removed to restore homeostasis?

Answer 15

C3b coats Ig-Ag complexes and delivers it to liver and spleen where they are cleared by phagocytes