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IMIN 371 > Ingham-9: T Cell Development II > Flashcards

Ingham-9: T Cell Development II Flashcards

1
Q

2 models of lineage commitment

A

instructive and stochastic model

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2
Q

What do cTECs express?

A

MHC I and MHC II plus self peptides

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3
Q

What do mTECs stand for?

A

medullary thymic epithelial cells

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4
Q

Function of mTECs

A

express tissue-specific Ags in thymus

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5
Q

What does AIRE stand for?

A

autoimmune regulator

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6
Q

What is AIRE used for?

A

Helps mTECs express tissue-restricted Ags

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7
Q

What is APECED?

A
  • immunodeficiency condition where AIRE genes are mutated

- results in autoimmune phenotypes (can get autoimmune diseases)

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IMIN 371 (18 decks)

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