Magor-6a

Question 1

What is the common feature of tumours that allow them to be killed?

Answer 1

Low or absent cell surface MHC (missing self)

Question 2

Where do NK cell usu. develop?

Answer 2

thymus

Question 3

Are NK cells lymphoid or myeloid heritage?

Answer 3

lymphoid

Question 4

What is NK cell’s hypothesized primary function?

Answer 4

remove stressed or virally infected cells (self)

Question 5

Difference between classical and non-classical MHC?

Answer 5

Classical MHC molecules bind peptide in a groove while non-classical MHC does not

Question 6

What anchors the pathogen peptide in the MHC groove?

Answer 6

invariant anchor residues in peptide groove of MHC

Question 7

What do non-classical MHC-like genes encode?

Answer 7

Proteins that do not bind peptide

Question 8

Example of what a non-classical MHC would bind

Answer 8

lipid antigens

Question 9

What type of MHC is CD1 (classical or not)?

Answer 9

non-classical

Question 10

What does CD1 molecule bind?

Answer 10

lipids derived from bacteria or self

Question 11

KIR stands for?

Answer 11

Killer Ig-like Receptor

Question 12

What does lectin normally bind?

Answer 12

carbohydrates

Question 13

What receptor did humans evolve for their NK cells?

Answer 13

KIRs

Question 14

Why is KIR an odd lectin?

Answer 14

It binds protein and not lipids

Question 15

What are the key inhibitory MHC I molecules?

Answer 15

HLA-A, B, C, and E

Question 16

What would happen to a virus that turns off MHC expression?

Answer 16

It becomes a target for NK cell

Question 17

What protein would a stressed cell turn on?

Answer 17

nonclassical MHC MIC (A or B)

Question 18

What does “licensed” mean for an NK cell?

Answer 18

An inhibitory receptor of NK cell has been turned off (verifying)

Question 19

Allorecognition?

Answer 19

Ability to recognize that another individual of a different species is not self

Question 20

What do NK cells release when they receive signals from a target cell?

Answer 20

perforin and granzyme B

Question 21

What is perforin a homologue of in the MAC?

Answer 21

C9

Question 22

What does Granzyme B do?

Answer 22

initiates apoptosis in target cell

Question 23

What does the TcR of a NK-T cell recognize?

Answer 23

glycolipids in CD1d

Question 24

What is CD1d?

Answer 24

nonclassical MHC I

Question 25

Do NK-T cells form memory cells?

Answer 25

No

Question 26

What can NK-T cells release?

Answer 26

cytokines

Question 27

Function of NK-T cells?

Answer 27

• antibacterial innate cell

- regulatory cell