Magor-5

Question 1

Examples of pAPCs

Answer 1

DC, macrophages and monocytes

Question 2

What do pAPCs secrete?

Answer 2

cytokines and chemokines

Question 3

When do pAPCs arise?

Answer 3

When they encounter pathogens

Question 4

What do pAPCs do for Th cells?

Answer 4

Upregulate co-stimulatory molecules needed for Th cell activation

Question 5

What is the only pAPC that can activate a naive Th cell?

Answer 5

DC

Question 6

What MHC is used for the exogenous pathway?

Answer 6

MHC 2

Question 7

What MHC is used for the endogenous pathway?

Answer 7

MHC 1

Question 8

Activated pAPCs make more ______ which make peptides that are better suited for MHC presentation

Answer 8

immuno-proteosomes

Question 9

When does Th activation occur?

Answer 9

When Th cell’s TCR recognizes pathogen bound to MHC of a pAPC

Question 10

How can DC direct type of Th cell that emerges?

Answer 10

Depending on which PRR get activated on DC, different cytokines can be made –> directs the type of immune response

Question 11

What does IL-17 do?

Answer 11

pro-inflammatory

Question 12

What does IL-10 and TGF-beta do?

Answer 12

regulatory “brakes”

Question 13

What does IL-4,5,13 do?

Answer 13

pro-antibodies

Question 14

Where do interactions of DC cytokine release to convert naive Th cells into mature ones happen?

Answer 14

secondary lymphoid organs

Question 15

What needs to happen during complete B-cell activation?

Answer 15

• B cells binds antigen on BCR

- B cell internalizes and loads pathogen on MHC

Question 16

The digestion products released by phagocytic cells can be carried by _____ to nearest draining ___ ____

Answer 16

lymph: lymph node

Question 17

Why does lymph carry pathogen molecules to lymph nodes?

Answer 17

So B cells can test whether their BCR (membrane Ab) will bind the molecules

Question 18

What cell can also transport intact Ag to lymph node?

Answer 18

DC

Question 19

What does IFN-gamma do?

Answer 19

antiviral, pro-Tc