M4 L5 Flashcards

1
Q

4 functions of antibodies

A

1) neutralization
2) opsonization
3) bind complement
4) can cross placenta for maternal antibody transfer

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2
Q

what happens when memory cells die?

A

lose immunity = get sick

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3
Q

how does the APC cell know what to tell the T cell?

A

ABC bind to tol like receptors and results in diff types of cytokines secreted = diff cytotoxic T cell subsets

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4
Q

primary lymphoid tissues (2)

A

bone marrow (B cells) & thymus (T cells)

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5
Q

What happens to T cell function as you age?

A

it shrinks = T cell production decreases = harder to activate B cells b/c of less T cells

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6
Q

secondary lymphoid tissues (3)

A
  • lymph nodes
  • spleen
  • peyers patch
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7
Q

peyers patch location

A

only found in intestines

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8
Q

T or F: memory & naive cells live in different areas

A

T

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9
Q

where are memory cells found

A

under skin

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10
Q

naive T & B cells circulate between ( ) via blood

A

lymph nodes

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11
Q

memory T & B cells circulate from ( ) to ( ) and then drain to nodes

A

blood, tissues

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12
Q

T or F: lots of diff cells found in lymph node

A

T

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13
Q

how do things enter vs leave lymph node?

A

enter- afferent vessel
leave - efferent vessel

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14
Q

when do cells leave the lymph node?

A

when they are activate

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15
Q

3 mucosal sites

A

intestine, lung & reproductive

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16
Q

peyers patches function & components

A

areas highly concentrated in diff types of immune cells to try survey antigen
- M cells sample antigen
- IgA response
- tolerance -> not responding to everything

17
Q

T or F: all mucosal systems are connected

A

T

18
Q

what happens if M & dendritic cells respond to antigen?

A

activate & drain through mesenteric system

19
Q

how are autoimmune diseases formed?

A

T cells attack your own cells

20
Q

how does coupling of self antigen to a large carrier molecule overcome mechanisms of self/non-self discrimination?

A

if carrier is next to self antigen, it learns to recognize this antigen
- the B cell will recognize the large carrier & T cell together = always respond to it