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ANBI 470 > M4 L3 > Flashcards

M4 L3 Flashcards

1
Q

MHC I

A
  • found on all nucleated cells
  • intracellular
  • partially degraded & presented on cell surface
  • viral, tumor surveillance
  • cytotoxic T cells
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2
Q

MHC II

A
  • found on antigen presenting cells
  • extracellular
  • proteins are degraded & presented on MHC II
  • viral particles, bacteria
  • T helper cells
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3
Q

purpose of MHC I/II

A

ensures that entire body is being surveillanced for pathogens

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4
Q

where are B cells produced & matured?

A

bone marrow

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5
Q

B cell function

A

recognize extracellular antigens via transmembrane antibodies
- 1 B cell only has 1 specificity

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6
Q

variable region

A

binds to antigen, determines antigen specificity

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7
Q

constant region

A

tells what the antibody isotype is to know what antibody we are making

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8
Q

how many diff possible combinations of antibody diversity

A

3x10^11

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9
Q

how many coding segments are there & what are they?

A

3 -> V,D,J

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10
Q

generation of antibody diversity use what kind of B cells?

A

naive

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11
Q

all antibody isotypes have different ( ) regions

A

constant

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12
Q

naive B cells

A

do not have function yet

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13
Q

how do naive B cells get activated?

A

when B cell meets antigen

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14
Q

3 classes of B cells

A

1) naive
2) Ab cells
3) memory cells

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15
Q

AB cells

A

have a function, try make copies of itself
- these are produced during clonal expansion

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16
Q

memory cells function

A

quicker production of antibodies = faster & bigger immune response

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17
Q

IgD

A

transmembrane, important for healthy B cells

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18
Q

IgM

A

transmembrane, activate complement & opsonization

19
Q

IgG

A

serum, activates complement & opsonization

20
Q

IgA

A

mucosal antibody

21
Q

what is the most abundant antibody

A

IgG

22
Q

what is the newest antibody

A

IgE

23
Q

IgE

A

parasite protection & produce histamine
- allergy antibody

24
Q

VDJ region

A

unique coding sequences for every naive B cell

25
Q

benefit of VDJ regiobn

A

now can make antibodies that can bind to anything

26
Q

T or F: rearrangement is permanent

A

T

27
Q

T or F: small changes in hinge regions produce very different functions

A

T

28
Q

what antibodies are monomers?

A

IgG, IgE & IgD

29
Q

steric hindrance

A

protein is trying to bind to another protein that it fits with

30
Q

what antibody is a pentamer? What is the benefit?

A

IgM -> good at complement = more binding strength

31
Q

what antibody is a diamer? What is the benefit?

A

IgA, prevents motility of bacteria if IgA binds to it

32
Q

neutralization

A

prevention of function

33
Q

T or F: all antibodies have neutralizing functions

A

T

34
Q

histamine function

A

stops sensitization of mast cells

35
Q

2 types of T cells

A

1) T helper cells
2) Cytotoxic T cells

36
Q

T helper cells

A

recognize MHC II
- secrete cytokines
- activate B cells, cytotoxic T cells, macrophages & neutrophils

37
Q

cytotoxic T cells

A

recognize MHC I
- kill infected cells
- can differentiate viruses

38
Q

what happens if there are no T helper cells?

A

no activated immune system = will not respond to anything

39
Q

3 types of antigen presenting cells (APCs)

A

1) macrophages/dendritic cells
2) B cells
3) MHC II bearing cells

40
Q

how can B cells act as APCs?

A

present antigen & respond to antigen

41
Q

CD4 vs CD8

A

CD4= T helper cells
CD8= cytotoxic T cells

42
Q

CD4 tells us about the

A

function

43
Q

T cell receptor looks for

A

antigen on MHC I or II

ANBI 470 (23 decks)

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