M1: Extension of Mendelian Genetics Flashcards
Heterozygote has an intermediate phenotype. (1:2:1)
Incomplete/Partial Dominance
Heterozygote expresses the phenotype of both homozygotes. (1:2:1)
Codominance
Three or more alleles of the same gene.
Multiple alleles
Mutation resulting in non-fictional gene product.
Affect’s organisms viability and survival
Lethal alleles
The presence of just one copy of the allele results in the death of the individual
Dominant lethal allele
Lethal in homozygous recessive condition
Recessive lethal allele
Modifications of Dihybrid Ratio
- Combination of two gene pairs with two modes of inheritance
- Single phenotype is affected by more than one set of genes
Cellular function of numerous gene products contributes to the development of a common phenotype.
Gene Interaction
Expression of one gene pair masks or modifies the effect of another gene pair
Epistasis
Allele that masks
Epistatic allele
Allele being masked
Hypostatic allele
Mask expression of the other gene pair
Antagonistic
Modifies the expression of other gene pair
Complementary
One gene when dominant, masks the effect of the other (12:3:1)
Dominant Epistasis
One gene, when homozygous recessive, hides or masks the effect of the other (9:3:4).
Recessive Epistasis
Either gene, when dominant, is epistatic to the other (15:1)
Duplicate genes
The presence of at least one dominant allele at each of the two gene pairs is essential to display the phenotype. (9:7)
Complementary Gene Interaction
New phenotypes result from the interaction between dominants or homozygous recessives (9:6:1)
Novel phenotypes
Other Modified Dihybrid Ratios
13:3
10:3:3
6:3:3:4
Multiple phenotypes effects of a single gene
Pleiotropy
Found in X chromosomes and a unique pattern of inheritance in comparison with autosomal gene
X-linked gene
X-linked gene: Homozygous, Heterozygous
Female
X-linked gene: Hemizygous
Male
Phenotype traits controlled by “it” are passed from homozygous mothers to al sons
Recessive X-linked genes
The expression of a specific phenotype is limited to one sex
Sex-limited inheritance
The sex of an individual influences the expression of the phenotype
Sex-influenced inheritance
Mitochondria is inherited from another cytoplasm.
Organelle Heredity
Factors affecting phenotypes in terms of “Genetic Background”
- Position Effect
- Genetic Anticipation
Factors affecting phenotypes in terms of “Environment”
- Temperature
- Light
- pH
- Elevation
- Nutrition
Factors affecting phenotypes in terms of “Degree of expression of a trait”
- Penetrance
- Expressivity
Percentage of individuals showing a degree of expression of a mutant genotype
Penetrance
Genotype is present but phenotype is not observable
Incomplete Penetrance
Measures the range of phenotype expression of a genotype
Expressivity
Trait is not manifested uniformly among individuals that show it
Variable expressivity