LIVER FUNCTION TEST part 1 Flashcards
What organ is the largest and most versatile organ in the body?
Liver
What is the weight of liver?
1.5 - 1.2 kg
What separates the two loves in the liver?
Falciform ligaments
carries blood from alimentary tract
Portal vein
carries oxygenated blood to the liver
Hepatic artery
What is the composition of Liver?
Lobules demarcated by CT septa and
vascular & biliary vessels
It is found in the center of the lobule and Parenchymal epithelial cells radiate from the vein.
Central Hepatic Vein
blood-carrying vascular channels on either side of the liver cell plates
Sinusoids
either endothelial cells or Kupffer cells
Lining cells
It is the largest group of fixed macrophages
endothelial cells or Kupffer cells
tissue space between the endothelial cells & hepatocytes
Spice of Disse
What fills the Space of Disse?
Interstitial fluid
What is the function of Spice of Disse?
It transfer nutrients and waste products from blood occurs
polygonal cells that constitute ~ 60% of the liver mass
Hepatocytes
What are the specialized surface of the cell?
Sinusoidal surface
Intercellular surface
Canalicular surface
TRUE OR FALSE:
Hepatic parenchymal cells have a underdeveloped organellar substructure.
FALSE ; developed
energy generation
Mitochondria
What is the other name of Lysosomes?
Hydrolytic enzymes
degradative functions
Lysosomes
site of many functions: drug metabolism & bile acid SYNTHESIS
Endoplasmic reticulum
tubules & vesicles
Smooth ER
This organ function as: bilirubin conjugation, drug detoxification & cholesterol synthesis
Smooth ER
lamellar profile with ribosomes
Rough ER
synthesis of specific proteins (e.g. albumin, coagulation factors)
Rough ER
It functions as the “packaging process” of the cell
Golgi complex
produces lipoproteins (VLDL) ; Glycoprotein synthesis
Golgi Complex
maintain cell shape and provide contractile force
Microtubules and Microfilaments
Receives, processes & stores materials absorbed from the digestive tract
Microtubules and Microfilaments
What are the materials that are absorbed and stored from the DT?
amino acids
CHO
fatty acids
cholesterol
multiple plasma proteins
Synthesis
Main organ of detoxification
Major site of catabolism of hormones
Microtubules and Microfilaments
These tests are done for liver function test
test for the proteins, bilirubin, ammonia and enzymes (ALT,AST, GTT, AGPT, SGOT)
What are the factors to be considered in doing Liver Function Tests?
Sensitivity
Specificity
Selectivity
