Lincosamides Flashcards

1
Q

what are the physicochemical properties of lincosamides?

A

lipid soluble
basic compounds

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2
Q

what is the distribution of lincosamides?

A

concentrate intracellularly and widely distributed

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3
Q

do lincosamides ever cross the blood brain barrier?

A

inflammation
clindamycin is used to treat toxoplasmosis

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4
Q

what is the mechanism of action of lincosamides?

A

inhibition of protein synthesis at 50S ribosomal subunit

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5
Q

why are gram negative bacteria resistant to lincosamides?

A

impermeable cell membranes and incompatible binding sites

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6
Q

what are some common agents of lincosamides?

A

lincomycin
clindamycin

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7
Q

what is a lincosamide that is an intramammary dairy cattle product?

A

pirlimycin

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8
Q

is clindamycin effective against anaerobes and B. fragilis?

A

yes

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9
Q

what is the four quadrant coverage of clindamycin?

A

E. coli: -
Staphylococcus: +
Streptococcus: +
anaerobe: +

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10
Q

who can we not use lincosamides in?

A

horses
rabbits
hamsters
guinea pigs

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11
Q

what do most adverse effects of lincosamides relate to?

A

gastrointestinal tract

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12
Q

what is a possible adverse effect of lincosamides in cats?

A

esophageal strictures

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13
Q

where do lincosamides concentrate?

A

tissues
lung
prostate
milk
macrophages

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14
Q

why is clindamycin used to treat toxoplasmosis?

A

lincosamides cross blood brain barrier with inflammation

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15
Q

are lincosamides bacteriostatic or bactericidal?

A

bacteriostatic

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16
Q

what group of bacteria are resistant to lincosamides?

A

gram negative

17
Q

is there cross-resistance between lincosamides?

A

yes, complete
also often cross-resistance with macrolides

18
Q

are lincosamides time-dependent or concentration-dependent?

A

time: recommended that it be above MIC for entire interval

19
Q

what microbes is clindamycin effective against?

A

Staphylococcus
Streptococcus
anaerobe
B. fragilis
Toxoplasmosis
Mycoplasma

20
Q

can you use any lincosamides in any hindgut fermenters?

A

no