Lesson 3 - Cells & Tissue Flashcards
they are the basic, living structural, and functional units of the body
Cells
Flexible sturdy barrier surrounds and contains the cytoplasm
Plasma Membrane
uses the fluid moseic model
Plasma Membrane
acts as a barrier separating inside and outside of the cell
Plasma Membrane
Controls the flow in and out of the cell
Plasma Membrane
helps identify cells to other cells
Plasma Membrane
participates in intercellular signaling
Plasma Membrane
Basic Structure of Plasma Membrane
Lipid Bilayer
2 back to back layers made up of 3 type of lipid molecules
Lipid Bilayer
Lipid bilayer made of what ? (3) what %?
Phospholipids 70%
Cholesterol 20%
Glycolipid 10%
Phospholipids, Cholesterol, Glycolipid are what type of molecules?
Amphephatic molecules
hydro
water
phelic
loving
____________ is polar part is phosphate containing the head which is _____________
- phospholipid
- hydrophilic
______________are the 2 long phatty acid tails which are________________
- non polar part
- hydrophobic
what are the two types of membrane proteins?
Integral Proteins
Peripheral Proteins
extend thru the lipid bilayer and are firmly embedded in it
Integral Proteins
many integral proteins are _________
glycoproteins
are ampiphatic
integral membrane proteins
carbohydrates portion of the glycolipid and glycoproteins form an extensive sugary quote called the ________
Glycocalex
acts like a molecular signature that enables cells to recognize one another
Glycocalex
enables cells to a-dire to one another in some tissues and protects cells from being digested by enzymes and extra cellular fluid
Glycocalex
Forms a pore through which a specific ion can flow to get across membrane.
Ion channel (integral)
Most plasma membranes include special channels for several common ions. What is this channel?
Ion channel (integral)
Transports a specific substance across membrane by undergoing a change in shape.
Carrier (integral)
For example, amino acids, needed to synthesize new proteins, enter body cells via carriers.
Carrier (integral)
are also known as transporters.
Carrier proteins
Recognizes specific ligand and alters cell’s function in some way.
Receptor (integral)
For example, antidiuretic hormone binds to receptors in the kidneys and changes the water permeability of certain plasma membranes.
Receptor (integral)
Catalyzes reaction inside or outside cell (depending on which direction the active site faces).
Enzyme (integral and peripheral)
For example, lactase protruding from epithelial cells lining your small intestine splits the disaccharide lactose in the milk you drink.
Enzyme (integral and peripheral)
Anchors filaments inside and outside the plasma membrane, providing structural stability and shape for the cell.
Linker (integral and peripheral)
May also participate in movement of the cell or link two cells together.
Linker (integral and peripheral)
Distinguishes your cells from anyone else’s (unless you are an identical twin).
An important class of such markers are the major
Cell identity marker (glycoprotein)
Movement of substances down a concentration gradient until equilibrium is reached
PASSIVE PROCESSES
do not require cellular energy in the form of ATP.
PASSIVE PROCESSES
Movement of molecules or ions down a concentration gradient due to their kinetic energy until they reach equilibrium.
Diffusion
Passive movement of a substance down its concentration gradient through the lipid bilayer of the plasma membrane without the help of membrane transport proteins.
Simple diffusion
Passive movement of a substance down its concentration gradient through the lipid bilayer by transmembrane proteins that function as channels or carriers.
Facilitated diffusion
Passive movement of water molecules across a selectively permeable membrane from an area of higher to lower water concentration until equilibrium is reached.
Osmosis
Movement of substances against a concentration gradient; requires cellular energy in the form of ATP
ACTIVE PROCESSES
requires cellular energy in the form of ATP.
ACTIVE PROCESSES
Active process in which a cell expends energy to move a polar or charged solutes. Substance across the membrane against its concentration gradient by transmembrane proteins that function as carriers.
Active Transport
Active process in which a substance moves across the membrane against its concentration gradient by pumps (carriers) that use energy supplied by hydrolysis of ATP.
Primary active transport
Coupled active transport of two substances across the membrane using energy supplied by a Na* or H* concentration gradient maintained by primary active transport pumps.
Secondary active transport
Antiporters move Na* (or H) and another substance in opposite directions across the membrane; symporters move Na (or H*) and another substance in the same direction across the membrane.
Secondary active transport
Active process in which substances move into or out of cells in vesicles that bud from plasma membrane
Transport in Vesicles
Active process in which substances move into or out of cells in vesicles that bud from plasma membrane; requires energy supplied by ATP
Transport in Vesicles
Movement of substances into a cell in vesicles.
Endocytosis
Ligand-receptor complexes trigger infolding of a clathrin-coated Ligands: transferrin, low-density lipoproteins. pit that forms a vesicle containing ligands.
Receptor-mediated endocytosis
“Cell eating”; movement of a solid particle into a cell after pseudopods engulf it to form a phagosome.
Phagocytosis
“Cell drinking”
Bulk-phase endocytosis
movement of extracellular fluid into a cell by infolding of plasma membrane to form a vesicle.
Bulk-phase endocytosis
Movement of substances out of a cell in secretory vesicles that fuse with the plasma membrane and release their contents into the extracellular fluid.
Exocytosis
Movement of a substance through a cell as a result of endocytosis on one side and exocytosis on the opposite side.
Transcytosis
Fluid mosaic lipid bilayer (phospholipids, cholesterol, and
glycolipids) studded with proteins; surrounds cytoplasm.
PLASMA MEMBRANE
Cellular contents between plasma membrane and nucleus-cytosol and organelles.
CYTOPLASM
Composed of water, solutes, suspended particles, lipid droplets, and glycogen granules.
Cytosol
network in the cytoplasm composed of three protein filaments: microfilaments, intermediate filaments, and microtubules.
cytoskeleton
Specialized structures with characteristic shapes.
Organelles
Pair of centrioles plus pericentriolar matrix.
Centrosome
Motile cell surface projections that contain 20 microtubules and a basal body.
Cilia and flagella
Composed of two subunits containing ribosomal RNA and proteins
Ribosome
may be free in cytosol or attached to rough ER.
Ribosome
Membranous network of flattened sacs or tubules.
Endoplasmic reticulum
covered by ribosomes and is attached to the nuclear envelope
Rough Endoplasmic reticulum
lacks ribosomes.
Smooth Endoplasmic reticulum
Consists of 3-20 flattened membranous sacs called cisternae
Golgi complex
structurally and functionally divided into entry (cis) face, medial cisternae, and exit (trans) face.
Golgi complex
Vesicle formed from Golgi complex
Lysosome
contains digestive enzymes.
Lysosome
contains digestive enzymes.
Lysosome
Vesicle containing oxidases
oxidative enzymes
decomposes hydrogen peroxide
catalase
new peroxisomes bud from preexisting ones.
Peroxisome
Tiny barrel-shaped structure that contains proteases
Proteasome
Consists of an external and an internal mitochondrial membrane, cristae, and matrix
Mitochondrion
new mitochondria form from preexisting ones.
Mitochondrion
Consists of a nuclear envelope with pores, nucleoli, and chromosomes, which exist as a tangled mass of chromatin in interphase cells.
NUCLEUS
Period between cell divisions; chromosomes not visible under light microscope.
Interphase
Metabolically active cell duplicates most of its organelles and cytosolic components
G1 phase
replication of chromosomes begins. (Cells that remain in the G, phase for a very long time, and possibly never divide again, are said to be in the Go phase.)
G1 phase
Replication of DNA and centrosomes.
S phase
Cell growth, enzyme and protein synthesis continue; replication of centrosomes complete.
G2, phase
Parent cell produces identical cells with identical chromosomes; chromosomes visible under light microscope.
Mitotic phase
Nuclear division; distribution of two sets of chromosomes into separate nuclei.
Mitosis
Chromatin fibers condense into paired chromatids
Prophase
nucleolus and nuclear envelope disappear; each centrosome moves to an opposite pole of the cell.
Prophase
Centromeres of chromatid pairs line up at metaphase plate.
Metaphase
Centromeres split
Anaphase
identical sets of chromosomes move to opposite poles of cell.
Anaphase
Nuclear envelopes and nucleoli reappear
Telophase
chromosomes resume chromatin form
Telophase
mitotic spindle disappears.
Telophase
Cytoplasmic division
Cytokinesis
contractile ring forms cleavage furrow around center of cell, dividing cytoplasm into separate and equal portions.
Cytokinesis
Tetrads line up along the metaphase plate
Metaphase I
Homologous chromosomes separate (sister chromatids remain together)
Anaphase I
Each cell has one of the replicated chromosomes from each homologous pair of chromosomes (n)
Telophase I
Mitosis: Cell Type
Somatic
Mitosis: Number of Divisions
1
Mitosis: Stages
- Interphase
- Prophase
- Metaphase
- Anaphase
- Telophase
Mitosis: Copy DNA?
Yes, interphase
Mitosis: Tetrads ?
No
Mitosis: Number Of Cells
2
Mitosis: Number Of Chromosomes per cell
46 or two sets of 23
Meiosis: Cell Type
Gamete
Meiosis: Number Of Division
2
Meiosis: Stages
- Interphase I only
- Prophase I and II
- Metaphase I and II
- Anaphase I and II
- Telophase I and II
Meiosis: Copy Of DNA ?
Yes, Interphase I
No, Interphase II
Meiosis: Tetrads ?
Yes
Meiosis: Number Of Cells
4
Meiosis: Number Of Chromosomes
23, makeup called haploid
The two identical chromosomes that result from DNA replication are referred to as
sister chromatids
The loss of tissue differentiation and function that is characteristic of most malignancies.
Anaplasia
Plasia
To shape
An
Not
A decrease in the size of cells, with a subsequent decrease in the size of the affected tissue or organ; wasting away.
Atrophy
Trophy
Nourishment
At
Without
Dys
Abnormal
Alteration in the size, shape, and organization of cells due to chronic irritation or inflammation; may progress to neoplasia (tumor formation, usually malignant) or revert to normal if the irritation is removed.
Dysplasia
Increase in the number of cells of a tissue due to an increase in the frequency of cell division.
Hyperplasia
Increase in the size of cells without cell division.
Hypertrophy
The transformation of one type of cell into another.
Metaplasia
Meta
Change
Offspring or descendants.
Progeny
Pro
Forward
Geny
Production
Ptoeo
Protein
all of an organism’s proteins
Proteome
The study of proteome in order to identify all of the proteins produced; it involves determining the three-dimensional structure of proteins so that drugs can be designed to alter protein activity to help in the treatment and diagnosis of disease.
Proteomics
A substance introduced into circulation by tumor cells that indicates the presence of a tumor, as well as the specific type.
Tumor marker
is a major difference between epithelial tissue and connective tissue.
The ratio of cells to extracellular matrix
is found between an epithelial tissue and a connective tissue.
The basement membrane
is a single layer of flat cells that resembles a tiled floor when viewed from apical surface: centrally located nucleus that is flattened and oval or spherical in shape.
Simple squamous epithelium
a single layer of cube-shaped cells; round, centrally located nucleus. Cuboidal cell shape is obvious when tissue is sectioned and viewed from the side.
Simple cuboidal epithelium
forms pigmented epithelium at posterior surface of retina of the eye; lines kidney tubules and smaller ducts of many glands
Simple cuboidal epithelium
makes up secreting portion of some glands such as thyroid gland and
ducts of some glands such as pancreas.
Simple cuboidal epithelium
is a single layer of nonciliated columnlike cells with oval nuclei near base of cells
Nonciliated simple columnar epithelium
contains 1 columnar epithelia cells with microvilli at apical surface and 2 goblet cells.
Nonciliated simple columnar epithelium
fingerlike cytoplasmic projections. increase surface area of plasma membrane thus increasing cell’s rate of absorption.
Microvilli
are modified columnar epithelial cells that secrete mucus. a slightly sticky fluid, at their apical surraces. Before release, mucus accumulates in voder portion of cell, causing it to bulge and making the whole cell resemble a goblet or wine glass
Goblet cells
Lines pastrointescinal trace trom stomach to anus, duccs ol many glands, and galloladder.
Nonciliated simple columnar epithelium
Secretion and absorption: larger columnar cells contain more organelles and thus are capable ot higher level ot secretion and absorption than are cuboidal cells.
Nonciliated simple columnar epithelium
secreted mucus lubricates linings of digestive, respiratory, and reproductve tracts, and most of urinary tract; helps prevent destruction of stomach lining by acidic gastric juice secreted by stomach.
Nonciliated simple columnar epithelium
is a single layer of ciliated columnlike cells with oval nuclei near base of cells. Goblet cells are usually interspersed
Ciliated simple columnar epithelium
Lines some bronchioles (small tubes) of respiratory tract, uterine (fallopian) tubes, uterus, Some paranasal sinuses, central canal of spinal cord, and ventricies of the brain.
CILIATED SIMPLE COLUMNAR EPITHELIUM
Cilia beat in unison, moving mucus and foreign particies toward throat, where they can
be coughed up and swallowed or spit out. Coughing and sneezing speed up movement
of cilia and mucus. Cilia also help move oocytes expelled from ovaries through uterine
(fallopian) tubes into uterus.
CILIATED SIMPLE COLUMNAR EPITHELIUM
appears to have several layers because the nuclei of the cells are at various levels.
Nonciliated pseudostratified columnar epithelium
Even though all the cells are attached to the basement membrane in a single layer, some cells do not extend to the apical surface. When viewed from the side, these features give the false impression of a multilayered tissue
Nonciliated Pseudostratified Columnar Epithelium
Contains cells without cilia and also lacks globlet cells.
Pseudostratified epithelium
Lines epididymis, larger ducts of many glands, and parts of male urethra.
NONCILIATED PSEUDOSTRATIFIED COLUMNAR EPITHELIUM
Absorption and secretion.
NONCILIATED PSEUDOSTRATIFIED COLUMNAR EPITHELIUM
appears to have several layers because cell nuclei are at various levels. All cells are attached to basement membrane in a single layer, but some cells do not extend to apical surface.
CILIATED PSEUDOSTRATIFIED COLUMNAR EPITHELIUM
When viewed from side, these features give false impression of a multilayered tissue
Ciliated pseudostratified columnar epithelium
Contains cells that extend to surface and secrete mucus evobler cents or bear cilla
pseudostratified
Lines airways of most of upper respiratory tract.
CILIATED PSEUDOSTRATIFIED COLUMNAR EPITHELIUM