(LESSON 12) Central and Peripheral Nervous System Flashcards
Brain at week 4
Arises as the rostral part of the neural tube in embryo, immediately starts to expand. Constrictions that define three primary brain vesicles appear.
Three early vesicles of brain
-prosencephalon (forebrain) -mesencephalon (midbrain) -rhombencephalon (hindbrain) Caudal portion of tube becomes spinal cord
brain at week 5
3 primary vesicles give rise to 5 secondary brain vesicles.
- Prosencephalon divides into
- telencephalon (endbrain)
- diencephalon (interbrain)
- Mesencephalon remains
- Rhombencephalon divides into
- metencephalon (afterbrain)
- myelencephalon (brain most like spinal cord)
Also develops two major bends:
- midbrain flexure
- cervical flexure
![](https://s3.amazonaws.com/brainscape-prod/system/cm/088/633/651/a_image_thumb.jpg?1659421981)
Telencephalon Development
Has two lateral swellings that look like mouse ears and develop into the two cerebral hemispheres of the cerebrum.
Lateral Ventricles
Diencephalon development
Thalamus, hypothalamus, epithalamus, third ventricle
Mesencephalon development
Forms midbrain, brain stem. Cerebral aqueduct
Metencephalon development
brainstem: pons, cerebellum, part of fourth ventricle.
Myelencephalon development
medulla oblongata, part of fourth ventricle
Embryonic Development of the brain
(image)
![](https://s3.amazonaws.com/brainscape-prod/system/cm/088/635/047/a_image_thumb.png?1659421982)
Cerebral Cortex
Gray matter of the brain and is 2-4cm thick. Gives us consciousness and enables voluntary action. Bilateral and divided into the sensory (precentral gyrus) and motor (postcentral gyrus) areas.
Sensory Areas
(Cortical Areas)
cortical areas involved with conscious sensation
Motor areas
(Cortical Areas)
cortical areas that control motor functions
Multimodal Association Areas
(Cortical Areas)
Cortical areas tie sensory information together with memory
Lateralization of Cortical Functioning
Left hemisphere:
- language
- math
- logic
Right hemisphere:
- visual-spatial skills
- emotion
- art
- music
Cerebral White Matter
- deep to the gray matter of the cortex
- provides communication for gray matter
- association fibers connect different parts of the same hemisphere.
- projection fibers ascend or descend to or from (respectively) the cerebral cortex.
- commissures are nerve fibers that run between the two hemispheres. (largest=corpus callosum)
Diencephalon
- surrounded by the cerebrum
- composed of
- thalamus: “gateway to the cerebral cortex”
- hypothalamus: main visceral control center
- epithalamus: contains the pineal gland which secretes melatonin.
Hypothalamus
- autonomic control center
- emotional response center
- body temperature regulation
- hunger and thirst sensations
- control of motivational behavior
- regulation of sleep-wake cycles
- control of endocrine system
- formation of memory
Disorders caused by injury to hypothalamus
- severe weight loss or obesity
- sleep disturbances
- dehydration
- emotional disorders
Cerebellum (little brain)
processes inputs from the
- cerebral motor cortex
- brain stem nuclei
- sensory receptors
- provides the timing and patterns of skeletal contraction
Cerebral Spinal Fluid
- Made mostly in choroid plexus
- About 1 liter/day is produced
- gives buoyancy (reduces the weight of the brain by 97 percent)
- cushions
- nourishes (hormones, vitamins, ions)
Meningitis
Caused when flow and drainage of the cerebral spinal fluid in the subarachanoid space and ventricles are blocked. Meninges inflames from bacterial or viral infection. Infection can spread to enderlying nervous tissue and cause brain inflammation called encephalitis.
Blood brain barrier
- maintains stable environment in the brain
- blood-borne substances separated from the brain by endothelial capillary walls with abundant tight junctions
- permeable to fat-soluble molecules, some anesthetics
Meninges
(image)
![](https://s3.amazonaws.com/brainscape-prod/system/cm/088/810/907/a_image_thumb.png?1659422053)
Alzheimer’s Disease
- Progressive degenerative disease that eventually results in dementia
- 5-15% over the age of 65 develop it
- Memory loss, shortened attention span, depression, and disorientation.
- Structural changes (areas associated with memory):
- basal forebrain nuclei
- hippocampus
- association areas of cerebral cortex
- Brain tissue contains senile plaques containing amyloid-beta peptide (between neurons), caused by an APP (amyloid precursor protein) build up, and neurofibrillar tangles (within neurons)
Peripheral Nervous System
Comprised of all neuron structures outside the CNS. Divided into cranial and spinal nerves.
Efferent Neurons vs Afferent Neurons
Efferent=conducting messages away from CNS towards an effector organ such as a muscle or gland.
Afferent=conducting sensory information towards the CNS.
Autonomic Nervous System
- part of the efferent (motor) division of the PNS
- motor innervation of smooth and cardiac muscle and glands
Sympathetic vs Parasympathetic
(divisions of ANS)
- Sympathetic: fight or flight
- Parasympathetic: vegetative function (digestion and resting)
Gustation
Taste.
- Papilla on tongue contain taste buds
- Saliva dissolves stimulating molecules (in foods) which bind to the microvilli cell membrane
- Innervation of taste receptors through facial and glossopharyngeal nerves
Olfactory Epithelium
Epithelium on the roof of the nasal cavity/superior nasal concha/superior nasal septum. Pseudostratified columnar epithelium that contain bipolar neurons called **olfactory receptor cells. **These are surrounded by columnar **supporting cells. **