Lesson 10 Flashcards
The chemicals (drugs) used to treat diseases are referred to as
Chemotherapeutic agents
Any drug used to treat diseases
Chemotherapeutic agents
The chemotherapeutic agents used to treat infectious disease
Antimicrobial agents
The “Father of Chemotherapy”
Paul Erhlich
Proved effective in treating syphilis
Salvarsan
Salvarsan is also known as
Compound 606
Drugs used to treat bacterial disease
Antibacterial agents
Drugs uswd to treat virus
Antiviral agent
A substance produced by a microorganism that is effective in killing or inhibiting the growth of other microorganisms
Antibiotic
Are all antibiotics an antimicrobial agents?
Yes
Are all antimicrobial agents an antibiotic
No
Example of antibiotics produced by moulds
Penicillin and Cephalosporin
Inhibit the production of folic acid in those bacteria that require p-aminobenzoic acid
Sulfonamide drugs
Inhibit growth of bacteria
Static
They kill EITHER gram negative or positive bacteria
Narrow spectrum antibiotics
They kill BOTH gram negative or positive bacteria
Broad Spectrum Antibiotics
It destroys gram positive bacteria
Vancomycij
They destroy gram negative bacteria
Colistin and nalidixic acid
Major categories of antibacterial agents
PCTAMF
Penicillin
Cephalosporin
Tetracycline
Aminoglycosides
Macrolides
Fluoroquinolones
Referred to a B-lactam drugs
Penicillin
Molecular structure includes a four sided ring structure known as
B-lactam ring
Clostridium perfringes
Anaerobic bacteria
Treponema pallidum
Spirochetes
Staphylococcus aureus, streptococcus pneumoniae
Gram positive cocci
Are B-lactam antibiotics, and like penicillin are produced by moulds
Cephalosporin
What generation:
Active against gram positive bacteria
First generation
What generation:
Active against gram negative bacteria
Second generation
What generation:
Even greater activity against gram negative bacteria
Third generation
Active against both positive and negative bacteria
Fourth gen
Broad spectrum drugs that exert their effect by targeting bacterial ribosomes
Tetracycline
Broad spectrum drugs that inhibit bacterial protein synthesis
Aminoglycosides
Inhibit protein synthesis
Macrolides
Are effective against members of the family Enterobactericiae and P. Aeriginosa
Fluoroquinolones
Antibiotic against chalmydias, mycoplasmas, rickettsia, vibro cholerae, and spirochette
Tetracycline
Antibiotics effective against gram negative
Aminoglycosidwz
The use of two or more drugs simultaneously to kill all the pathogens
Multidrug therapy
Multiresistsnt strain of M. Tuberculosis
Rifampicin
Isoniazid
Pyrazinamide
Ethambutol
The use of two antimicrobial agents to treat an infectious disease produces a degree of pathogens
Synergism
When the use of two drugs produces an extent of pathogen killing
Antagonism
The first antiviral agent effective against HIV
zidovudine
Refers to an organism that is resistant to only one antimicrobial agent
Superbug
Resistant to antistaphylococcal drugs except vancomycin
MRSA AND MRSE
Have developed resistance to the usual dosages of vancomycin
VISA
Strains have been isolated that are resistant to even the highest practical doses of vancomycin
VRSQ
Strains are resistant to most anti-enterococcal drugs
VRE