Lecture 8 Its actually lupus Flashcards
Who is the classic presentation?
female of reproductive age, african descent
Certain HLA haplotypes such as ____ and ____ are increased in SLE with respect to the general population
DR2; DR3
Which 2 drugs are most associated with SLE?
procainainamide, hyrdalazine
What hormone may aggravate SLE symtpoms
estrogen
The x chromosome was more often ______ in women with SLE than without
demethylated
measurement of ANA:
tissue placed on slide–>patient’s ___ is placed on slide–>slide is washed, ___ tagged rabbit anti-human Ig is placed–>washed–>imaging
serum;
fluorecein
anti-___ antibodies are highly specific for SLE
dsDNA
Anti__ antibodies are an example of extractable nuclear antigens are are specific for SLE
smith (Sm)
Anti-RNP is associated with _______
mixed connective tissue disease
_____ antibodies and and lupus ____ can cause false positive VRDLs and a hypercoagulable state
anticardiolipin; anticoagulant
In lupus, IL _ is increased while IL _ is decreased
10, 12
____ of lymphocytes in patients with SLE has shown to be increased
apoptosis
MQ’s have difficulty clearing ___ cells in SLE patients–>increase in ___ antigens–>auto-immunity
apoptotic; self
2 areas most affected by immune complex disease:
kidney, blood vessels
Antiphospho lipid syndrome is due to lupus ____. It is associated with a ___- PTT and venous and arterial ____
anticoagulant; prolonged; thrombosis
Classic presentation:
rash, joint pain, fever
The arthritis is typical ____ but is not as ___ as RA
symmetric, erosive
___ sensitivity is very common, with rashes seen after exposure
sun
Which kind of rash in lupus leaves scars?
discoid
In a discoid rash, the central area becomes ___ while edges remain ___ and ____
atrophic;
edematous, erythematous
____ ulcers are common, but are generally ____
oronasopharyngeal; painless
What are osler nodes?
What is livedo reticularis?
local vasculitis;
fine lacy rash
____ such as pleurisy and pericarditis is very common
serositis
What is libman-sacks endocarditis?
wart-like vegetations on both sides of a heart valve; typically mitral
leuko____ is very common
penia
membranous glomerulonephritis is a ____ syndrome and is characterized by ____
nephrotic;
proteinuria
diffuse proliferative glomerulonephritis is a _____ syndrome and is characterize by ____
nephritic; hypertension, hematuria
____ is often seen and is due to vasospasm, causing decreased blood flow.
raynaud phenomenon
What is the most important criteria for diagnosis?
positive ANA test
The ANA test has high ___. The anti-dsDNA and anti-Smith antibodies have high ____
sensitivity;
specificity
Complements are typically _____ due to immune complex formation
depressed
____ exposure must be limited in SLE patients
sun
Antimalarial drugs such as ____ are useful in treatment
hydroxychloroquine
What 2 cytotoxic drugs are sometimes used?
azathioprine, cyclophosphamide
_____ ____ (cellcept) has been shown to be useful in cyclophosphamide resistant renal disease
mycophenolate mofetil
_____ is the greatest cause of death in SLE patients (According to his notes)
infection
