Lec 10 Scleroderma Flashcards
About 20% of patients with scleroderma have what antibody?
Anti endothelial cell cytotoxic factors
There is evidence scleroderma may be due to ____ that causes a graft vs host type disease
microchimerism
vaso_____ are important in the pathogenesis of scleroderma
constrictors
The ____ ____ may be a primary target tissue as evidenced by intimal sclerosis, fibrinoid change, and necrosis.
vascular endothelium
The is atrophy of skin ____ and loss of ____ ____ and ____ ____
appendages; hair follicles, sweat glands
Thinning of the ____ is also seen, with accumulation of excess ____ bundles and loss of ____ ____
epidermis; collagen; blood vessels
Changes in skin include puffy ____ and ____
face, hands
Skin changes over time:
____–>stiff with altered _____ –>atrophic
edematous; pigmentation
A characteristic skin finding is loss of _____
wrinkles
Raynouds phenomenon is often seen. In severe cases, these leads to ____ of the fingers and digital _____
infarction; pitting
____ dysmotility occurs in 90% of cases. Involvement of the ____ and ____ can lead to malabsorption
esophageal
duodenum, jejunum
In the colon, wide mouth ____ can occur
sacculations
In the kidney, slowly progressive ____ lesions with ____ proliferation may be seen
arterial; intimal
In the kidney, _____ ____ causes a gradual reduction in GFR
adventitial fibrosis
_____ ____ ____ is a sudden collapse of GFR that leads to severe volume depletion
scleroderma renal crisis
