Lecture 19 I Can't Believe It's Not Gout! (Pseudogout)

Question 1

Other name for pseudogout (aka what crystals are deposited)

Answer 1

calcium pyrophosphate deposition disease

Question 2

Diseases associated with pseudogout (3)

Answer 2

hemochromatosis, osteoarthritis, hyperparathyroidism

Question 3

description of CPP crystals:
shape = _______
polarized light?

Answer 3

rhomboid, weakly birefringent

Question 4

chondrocytes form high levels of _____ pyrophosphate that is complexed with calcium that deposits in the _____ matric

Answer 4

inorganic; pericellular

Question 5

CPP actions:

1. initiate ____
2. direct ____ effects on chondrocytes
3. alter mechanical properties of ____

Answer 5

inflammation;
catobolic;
cartilage

Question 6

most common distribution of inflammation?

Answer 6

knee and wrist (and shoulder)

Question 7

how long do attacks last?

How long do regular gout attacks last?

Answer 7

weeks to months;

days to weeks

Question 8

inflammatory response to CPP crystals:

Answer 8

warmth, swelling, erythema

Question 9

crowned dens syndrome:
crystals deposit around _____ vertebra
manifests as severe _____ pain, high ___, and high ____ markers. looks like ____

Answer 9

C3;
neck, fever, inflammatory;
meningitis

Question 10

first/second line treatment of acute attack:

Answer 10

joint injection of corticosteroid;

colchicine