Lecture 7 Sjogren's syndrom Flashcards
Sjogren’s syndrome (SS) is characterized by lymphacytic infiltration of the ____ glands, primarily the ____ and ____.
exocrine; lacrimal
salivary
HLA ___ is associated with SS
DR3
__ infection is also associated with development of SS
Viral
____ ___ cells expressing Antigen presenting proteins, promote adhesion, and costimulate T cells
glandular epithelial
Patients present with ____ ____, or dry eyes
keratoconjunctivitis sicca
____ like secretions may accumulate along the inner canthous
rope
The slit lamp shows superficial erosions of the ____ epithelium
corneal
What is the schirmer test?
measures wetness of paper after putting in eye;
____ ____ staining reveals destroyed conjunctival epithelium
rose bengal
Patients complain of ____, or dry mouth
xerostomia
Increased _____ _____ are associated with Dry mouth
dental caries
the ____ glands may also swell
parotid
Female patients may experience _____ ___
vaginal dryness
Neurologically, ____ ____ may be seen
peripheral neuropathy
Patients are much more likely to get what type of cancer?
lymphoma
____ dysmotility may occur in some patients
esophageal
What has been the gold standard for diagnosis?
salivary gland biopsy
____ measures unstimulated salivary flow
sialometry
Antinuclear antibodies associated with SS are SS-A (anti-__) and SS-B (anti-___)
rho; la
Occlusion of the _____ may help with dry eye by allowing tear pooling
puncta
Secretagogues stimulate the ____ receptors to stimulate tearing and salivary gland outflow
muscarinic
Examples of secretatogues include ____ and civimeline hydrochloride
pilocarpine
