Lecture 7 Sjogren's syndrom

Question 1

Sjogren’s syndrome (SS) is characterized by lymphacytic infiltration of the ____ glands, primarily the ____ and ____.

Answer 1

exocrine; lacrimal

salivary

Question 2

HLA ___ is associated with SS

Answer 2

DR3

Question 3

__ infection is also associated with development of SS

Answer 3

Viral

Question 4

____ ___ cells expressing Antigen presenting proteins, promote adhesion, and costimulate T cells

Answer 4

glandular epithelial

Question 5

Patients present with ____ ____, or dry eyes

Answer 5

keratoconjunctivitis sicca

Question 6

____ like secretions may accumulate along the inner canthous

Answer 6

rope

Question 7

The slit lamp shows superficial erosions of the ____ epithelium

Answer 7

corneal

Question 8

What is the schirmer test?

Answer 8

measures wetness of paper after putting in eye;

Question 9

____ ____ staining reveals destroyed conjunctival epithelium

Answer 9

rose bengal

Question 10

Patients complain of ____, or dry mouth

Answer 10

xerostomia

Question 11

Increased _____ _____ are associated with Dry mouth

Answer 11

dental caries

Question 12

the ____ glands may also swell

Answer 12

parotid

Question 13

Female patients may experience _____ ___

Answer 13

vaginal dryness

Question 14

Neurologically, ____ ____ may be seen

Answer 14

peripheral neuropathy

Question 15

Patients are much more likely to get what type of cancer?

Answer 15

lymphoma

Question 16

____ dysmotility may occur in some patients

Answer 16

esophageal

Question 17

What has been the gold standard for diagnosis?

Answer 17

salivary gland biopsy

Question 18

____ measures unstimulated salivary flow

Answer 18

sialometry

Question 19

Antinuclear antibodies associated with SS are SS-A (anti-__) and SS-B (anti-___)

Answer 19

rho; la

Question 20

Occlusion of the _____ may help with dry eye by allowing tear pooling

Answer 20

puncta

Question 21

Secretagogues stimulate the ____ receptors to stimulate tearing and salivary gland outflow

Answer 21

muscarinic

Question 22

Examples of secretatogues include ____ and civimeline hydrochloride

Answer 22

pilocarpine