Lec 9 Myositis Flashcards
Which form of myositis has the worse prognosis?
inclusion body myositis
The inflammatory infiltrate is typically predominantly ______
lymphocytes
Dermatomyositis is characterized by primarily ____ and _____ lymphocytic infiltrate
perivascular, perifasicular
There is _____ atrophy and fibrosis in dermatomyositis
perifasicular
Polymyositis is characterized by ____ inflammation ____ the fascicle
endomysial; within
Characteristic ____ lined ____ are seen in inclusion body myositis
intracellular vacoules
What are the 2 myositis specific antibodies?
Anti Jo1; Anti Mi 2
Anti Jo 1 is an antibody against _____
histidyl t-RNA synthetase
Anti Mi2 is an antibody against a ____
helicase
Muscle weakness is typically in the ___ muscles (ie shoulders
proximal
What are gottron papules?
flat plaques on the knuckles
What is a heliotrope rash?
erythmatous rash above the eyelids
What nail changes are often seen?
nail fold capillary changes–>hyperemic
What internal organ is often also affected?
What does it cause?
esophagus,
dysphagia
“___ hands” are a characteristic finding
mechanic’s
What 2 serum muscle enzymes are often elevated?
creatinine phosphokinase, aldolase
What other enzymes are often elevated?
transaminases, lactate dehydrogenase
The characteristic EMG shows increased _____ and general _____
recruitment; irritability
Inclusion body myositis is characterized by ____ response to ____
poor, corticosteroids
Common organ involvement that can lead to death:
lung, heart
____ muscle weakness can lead to increased infection risk
respiratory
There is an notable increased risk of ____ in these patients
cancer
Peak incidence of cancer is within ___ years of onset
2
What is probably the best “pivot point” in the ddx of myositis?
increased CPK
Anti ___ is associated with a good response, while anti ____ and ____ is associated with partial response
Mi2
Jo1, SRP
____ are the mainstay of treatment
corticosteroids
Besides corticosteroids, long-term _____ therapy may also be used
immunosupression
