Lecture 20 (0_0) Septic Arthritis Flashcards
inflammation of joint: infiltration of ____ and ____ causing a swollen, _____, and ______ joint
PMNs, phagocytes;
warm, painful
previous joint ____ or compromised ____ ____ are predisposing factors for septic arthrits
damage (ie RA, OA) host defenses (ie corticosteroid use)
most common gram + cocci that cause septic arthritis
staph aureus > streptococcus
_____ are more common causes of septic arthritis in the young, chronically ill, or IV drug users
gram neg bacilli
most gram - bacilliary septic arthritis are secondary to ____ or ____ infections
UTI, skin
____ is common in elderly patients. ____ and ____ are common in IV drug users. _____ can occur following animal bites
e. coli,
serratia, pseudomonas;
pasteurella multicoda
foul smelling fluid or air seen on joint x-rays should clue you to _____ bacterial infections
anaerobic
Vertebral ___ (_____ ____) accounts of skeletal septic arthritis
TB (pott’s disease)
PMN infiltrate causes a ____ synovial fluid. There is also neovascularization, synovial proliferations, ____ tissue, and cartilage ______
purulent;
granulation;
destruction
what causes the synovial/bone/cartilage necrosis in septic arthritis?
proteolytic enzymes released from PMNS in response to phagocytosed bacteria
classic presentation:
poly or monoarticular?
sudden or gradual pain?
____ and ____
monoarticular, suddenly painful, swollen and warm
What conditions most resemble septic arthritis>?
gout or pseudogout
when acutely hot, what should be done to the joint?
aspiration/drainage of joint asap
if gram positive cocci, use _____
if gram negative cocci, use ____
if gram negative rod, use ____
nafcillin or vanco if MRSA;
ceftriaxone;
aminoglycoside
____ deficiency is associated with with increased risk of Neisseria bacteremia
C5-C9 complement
