Lecture 15 Seroneg Spondys

Question 1

seronegative spondyloarthropathies are characterized by a lack of ______ and by inflammation of bony insertions of tendons and fascia known as ____

Answer 1

rheumatoid factor, enthesopathy

Question 2

what is strongly associated genetically with these disorders?

Answer 2

HLAB27 positive

Question 3

Is HLA B27 an MHC1 or MHC2?

Answer 3

MHC type 1, presents to CD8 cells

Question 4

What happened to the mouse that was injected with HLAB27?

Answer 4

developed characteristics of a human spondyloarthropathy

Question 5

Triad of reactive arthritis/reiter syndrome:

Answer 5

conjunctivitis, urethritis, arthritis

Question 6

diseases associated with development of reactive arthritis?

Answer 6

GI–shigella, salmonella, yersinia, campy

venereal–chlamydia

Question 7

Where is the primary site of pathology in reiter’s, and what is the change in tissue characterized by?

Answer 7

insertion of ligaments/capsules into bone (enthesis)

fibrosis, ossification

Question 8

do seronegative spondy’s typically affect men or women? what age?

Answer 8

men, young adults

Question 9

What area of the body is typically affected?

Answer 9

spine

Question 10

what disease is associated with the term “bamboo spine”

Answer 10

ankylosing spondylitis

Question 11

major characterisitc of ankylosing spondylitis

Answer 11

low back pain of insidious onset

Question 12

what seems to improve ankylosing spondylitits? is it worse during the day or at night?

Answer 12

exercise; night

Question 13

There is often loss of lumbar ____ and stiffening of the spine with loss of ____

Answer 13

lordosis; motion

Question 14

What does the schober test measure?

Answer 14

spinal distraction with bending

Question 15

up to 80% of male patients with ankylosing spondylitis have this extraarticular symptom

Answer 15

prostatitis; (eye is often strongly involved-uveitis)

Question 16

what cardiovascular disease is strongly associated with ankyl spondy?

Answer 16

aortitis

Question 17

ankylosing spondylitis may cause fusion of the _____ joint

Answer 17

sacro-illac

Question 18

Prognosis of ankyl spondy?
prognosis is good with regards to _____
bad with regards to _____

Answer 18

pain and function;

mobility

Question 19

when does reiter’s syndrome typically present relative to illness?

Answer 19

2-4 weeks after

Question 20

what is another name for dactylitis (as seen in Reiter’s and psoriatic arthritis)

Answer 20

sausage digit

Question 21

Achilles tendonitis in reiter’s is also known as _____

Answer 21

lovers heel

Question 22

Reiter’s: what is keratoderma blenorrhagica?

Answer 22

cobble stone skin lesions seeon soles, glans penis, and toes

Question 23

reiter’s: what is circinate balanitis?

Answer 23

painless, superficial erosions of glans penis

Question 24

Characteristic X-ray in psoriatic arthritis?

Answer 24

“needle in cup”

Question 25

changes in what are often associated as a non-articular aspect of psoriatic arthritis?

Answer 25

nail changes

Question 26

Psoriatic arthritis often has ‘____ ‘involvement, aka the involvement of all the joints on a digit

Answer 26

ray

Question 27

____ ____ is the name of a severely destructive lesion can also cause ____ glass hands in psoriatic arthritis

Answer 27

arthilitis mutilans;

opera

Question 28

____ digits can also be seen with psoriatic arthritis

Answer 28

telescoping

Question 29

classic skin areas of psoriasis?

___ of the nails is also seen

Answer 29

periumbilical area, elbow;

pitting

Question 30

Osteolytis with ____ ____ deformity is another name for the typical x-ray finding of psoriatic arthritis

Answer 30

fish tail

Question 31

What general disease is also associated with arthritic symptoms?

Answer 31

inflammatory bowel disease