Lecture 16 OsteoArthritis

Question 1

Formation of new bone at joint surfaces is called ____; formation of new bone in periarticular tissues is called ____

Answer 1

eburnation;

osteophyte formation

Question 2

the eitology of osteoarthritis is ____; joint wear and tear destroys articular _____

Answer 2

mechanical; cartilage

Question 3

Is this an age of old or young people?

men or women usually?

Answer 3

old; women

Question 4

Greatest modifiable risk factor?

Answer 4

obesity

Question 5

OA is associated with previous injury, neuroanatomically abnormal joints, and ____

Answer 5

weakness

Question 6

____ syndrome: COL2A1 gene is associated with hereditary arthoopthalmopathy (premature OA + eye isses)

Answer 6

stickler

Question 7

pathological changes: degradation of cartilage, thickening of ____ bone, formation of _____, and degeneration of _____

Answer 7

subchondral;
osteophytes
ligaments

Question 8

in OA, chrondrocytes become activated, characterized by cell _____ ,____ formation, and increased production of matrix _____ and _____ enzymes

Answer 8

proliferation, cluster;

proteins, degrading

Question 9

What kind of mineral deposition is often seen?

Answer 9

calcium

Question 10

what remodels/repairs quicker, bone or cartilage?

Answer 10

bone

Question 11

are synovial infiltrates seen with OA?

Answer 11

yes, but not as much as RA

Question 12

glycosaminoglycans become ____ and proteoglycans _____. water content _____

Answer 12

shorter, decreases;

increases

Question 13

Is the joint pain usually sudden or gradual?

does it get better or worse with rest?

Answer 13

gradual;

better

Question 14

_____ is crunching of the joint on range of motion tests

Answer 14

crepitus

Question 15

medial knee cartilage loss causes legs to bow ____. this is called genu ____

Answer 15

in (bow legged);

varus

Question 16

Heberdon nodes are located ____. Bouchard nodes are located ____. What is NOT invovled

Answer 16

DIP;
PIP;

MCP NOT INVOLVED

Question 17

lateral knee cartilage loss causes legs to bow ____. this is called genu ____

Answer 17

out; valgus

Question 18

is joint involvement assymetric or symmetric?

more or less involvement than RA?

Answer 18

assymetric;

less

Question 19

inflammatory OA has 3 characteristics that differentiate it from regular OA:

1. florid ______ components
2. radiographic _____ _____ changes
3. tendency for ______ joint _____

Answer 19

inflammatory;
subchondral erosive
interphalangeal joint ankylosis

Question 20

Joint aspiration shows ____ fluid

Answer 20

non-inflammatory

Question 21

____ wing deformity and peri-articular ____ are characteristic x-ray findigns inOA

Answer 21

gull; sclerosis

Question 22

_____ and joint space _____ are the most critical x-ray findings seen

Answer 22

osteophytes; loss

Question 23

pharmacological treatment includes _____, _____, and intra-articular _____

Answer 23

NSAIDS, acetaminophen, glucocorticoids