lecture 34 Flashcards
complement is carried in the what
the plasma
what lymphoid organs are rich in lymphocytes
the spleen and lymphnodes
what ways do dendritic cells move throughout the body
Dendritic cells are found in the skin but they migrate into lymph vessels then the draining lymph nodes. Or they are travelling in blood then move to the spleen.
whats an APC
an antigen-presenting cell
what cells are APCs but whats the most prolific
dendrites, macrophages and b cells. Dendritic cells are the most prolific
dendrites present what on their MHC receptors
they present peptide from antigen cells
what T cells are activated by MHC-2
the CD4 helper T cells
what cells are activated by MHC-1
the CD8 T cells
MHC-1 only shows what type of antigen
endogenous antigens
MHC-2 shows what antigen type
exogenous antigen
what type of cell has MHC-1 receptors
all except the red blood cell. all nucleated cells
what types of cell has MHC-1 and MHC-2
the antigen presenting cells
whats an endogenous antigen
intracellular antigens. Potentially the protein of a virus replicating inside the cell
whats an exogenous antigen
So only antigens taken up by phagocytosing something.
how does MHC-1 loading occur
Antigenic proteins are degraded to
peptides in cytoplasm.
* Peptides are imported into endoplasmic
reticulum (ER).
* Peptide loading of MHC-I takes place in
ER.
how does MHC-2 loading occur
Antigenic proteins are degraded in acidic
phagolysosome.
* Peptide loading of MHC-II takes place in
phagolysosome.
what can endogenous antigens be
Endogenous antigens are viral antigens or cancerous ones
what can be exogenous antigens
anything that has been phagocytosed from the cell
what does the T cell use to kill the virally infected cell
granzyme and perforin
whats the way the CD8 kills the cell
apoptosis
