endocrine flow charts Flashcards
insulin is secreted from where
the beta cells of pancreas
what causes insulin to be released
the increase of blood glucose concentration
insulin has an effect on what tissue cells
muscle cells and liver cells and adipose fat cells
what does insulin do to muscle and fat cells
muscle cell: causes net increase in uptake of glucose, as increased amino acid uptake and increased glycogen and protein synthesis.
fat cells sees increase in fat synthesis
what does insulin do to the liver cells
increases glycogen and fat synthesis, stops glucose output thereby increasing glucose intake.
whats the negative feedback for insulin release
the lowering of the blood glucose levels.
glucagon is secreted from where
the alpha cells of the pancreas
what is the stimulus for glucagon secretion
low blood sugar
what are the target cells of glucagon
the cells of the liver
what type of hormones are insulin and glucagon
peptide, water-soluble hormones
what does glucagon do to the target liver cells
increases breakdown of glycogen (glycogenolysis)
increases glucose synthesis (gluconeogenesis)
increases ketone synthesis
what is the negative feedback for glucagon secretion
the raise of blood glucose concentration and blood ketone concentration
what hormones can also raise blood glucose concentration
growth hormone, adrenaline and cortisol
what triggers the release of GH-RH
The stimulus for GH-RH release is neural input to the hypothalamus.
where is GH-RH hormone stored and secreted from
in GH-RH neurons in the hypothalamus
what are the target cells for GH-RH
the target cells are in the anterior pituitary gland.
what does the GH-RH signal cause in the anterior pituiary lobe
it signals the release of growth hormone from the anterior pituitary
what are the target cells for GH
muscle cells, liver cells, fat cells,
what does the hormone GH cause in the liver cells
it directly causes glucose synthesis in the liver, but also causes the secretion of another hormone, somatomedin C which has indirect effects
what inderect effects does IGF 1 have
somatomedin c, or IGF 1 promotes the growth of bones, muscle and other tissues, which promotes cell division
what effects does GH have on muscle cells
stimulates protein synthesis (long term) and inhibits, cellular uptake of glucose (short term)
what effect does GH have on fat cells
increases triglyceride breakdown in adipose tissue
(short term).
whats the negative feedback for the release of GH
the IGF-1 has negative feedback on the GH-RH neurons, slowing the release of GH-RH to the pituitary
what other effect does IGF-1 have
it causes positive feedback on the release of GH-IH from the somatomedin neurons
what does GH-IH do
it inhibits the release of GH from the anterior pituitary
what triggers the start of the thyroid hormone flow chart
external and internal stimuli lead
to CNS input to hypothalamus