Lecture 3 - Examples of Autocrine and Paracrine Regulators Flashcards
- produced by many organs, particularly the liver and cartilages
- for growth and cell division
insulin-like growth factors (somatomedins)
produces insulin-like growth factors (somatomedins)
- liver
- cartilage
major actions of insulin-like growth factors (somatomedins)
- growth
- cell division
- produced by endothelium of blood vessels; neurons; macrophages
- acts in dilation of blood vesses; neural messenger; antibacterial agent
nitric oxide
produces nitric oxide
- endothelium of blood vessels
- neurons
- macrophages
major actions of nitric oxide
- endothelium of blood vessels = dilation
- neurons = neural messenger
- macrophages = antibacterial agent
- produced by endothelium of blood vessels, and other organs
- for constriction of blood vessels and other effects
endothelins
produces endothelins
- endothelium of blood vessels
- other organs
major actions of endothelins
- constriction of blood vessels
- other effects
- produced by platelets; macrophages; vascular smooth muscle cells
- responsible for cell division within blood vessels
platelet-derived growth factor
produces platelet-derived growth factor
- platelets
- macrophages
- vascular smooth muscle cells
major action of platelet-derived growth factor
cell division within blood vessels
- produced by epidermal tissues
- responsible for cell division in wound healing
epidermal growth factos
produces epidermal growth factos
epidermal tissues
major action of epidermal growth factos
cell division in wound healing
- produced by Schwann cells and neurons
- responsible for regeneration of peripheral nerves
neurotrophins
produces neurotrophins
- Schwann cells
- neurons
major action of neurotrophins
regeneration of peripheral nerves
- produced by endothelium blood vessels
- for dilation of blood vessels
bradykinin
produces bradykinin
endothelium of blood vessels
major actions of bradykinin
dilation of blood vessels
- produced by macrophages; lymphocytes
- for regulation of immune system
interleukins (cytokines)
produces interleukins (cytokines)
- macrophages
- lymphocytes
major actions of interleukins (cytokines)
regulation of immune system
- produced by almost all nucleated cells
- can activate or inhibit (prevent) platelet buildup for blood clot formation.
- Cause vasodilation (widening of blood vessels) or vasoconstriction (narrowing of blood vessels).
- Cause bronchoconstriction (the narrowing of air passageways) or bronchodilation (widening of air passageways)
Prostaglandins
produces prostaglandins
almost all nucleated cells
some of the major actions of prostaglandins
- activate or inhibit platelet buildup
- vasodilation or vasoconstriction
- bronchoconstriction or bronchodilation
- produced by macrophages; adipocytes
- responsible for a diverse range of signalling events within cells, leading to necrosis or apoptosis
TNFα (tumor necrosis factor alpha)
produces TNFα (tumor necrosis factor alpha)
- macrophages
- adipocytes
major functions of TNFα (tumor necrosis factor alpha)
proliferation, differentiation, and apoptosis of different cells (ex. neurons, ostioblasts)