Lecture 16- Lower GI cancer Flashcards

1
Q

Symptoms of lower GI cancers:

A
  • Obstruction
  • PR bleeding
  • Change in bowel habit
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

Obstructions

A

Anything that causing a blockage in the bowl

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

red flags associated with obstruction

A
  • Weight loss
  • Unexplained abdominal pain
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

General symptoms of obstruction

A
  • Abdominal distension – how much air on x-ray
  • Abdominal pain
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

benign causes of obstructions

A
  • Volvulus- twisting of the bowel
  • Diverticular disease
  • Hernias
  • Strictures
  • Pyloric stenosis
  • Intussusception – intestine slides inside another part
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

malignant causes of obstruction vary

A

based on location

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

small intestine malignancy and obstruction

A
  • If obstructions higher up pressure builds up backwards vomiting first
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

small intestine malignancy and obstruction

A
  • Would have to have very significant build up to cause vomiting
  • Causes absolute constipation- no wind or faeces
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

PR bleeding Red flags

*

A
  • Anyone 40 with unexplained weight loss /abdo pain should be considered
  • > 50 with iron deficiency, anaemia and change in bowel habit
  • Tenesmus- feeling the need to defaecate and defecating but still feel like there is something still there after finished
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

benign causes of PR bleeding

A
  • Haemorrhoids
  • Anal fissures
  • IBD
  • Diverticular disease
  • Infective gastroenteritis
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

PR bleeding with S.intestine origin

A

melaena- more time to oxidise

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

PR bleeding with L.intestine origin

A
  • Fresher bright red?
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

Change in bowel habits- Red flags

A
  • Age dependent
  • Weight loss
  • Iron deficiency anaemia
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

change in bowel habits

  • ‘What is normal for the patient?’*
  • x
A

‘What is normal for the patient?’

  • Change in frequency
  • Change in consistency
  • Associated symptoms
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

benign causes of change in bowel habits

A
  • IBD
  • Thyroid
  • Coeliac
  • IBS
  • medication
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

large boweel cancer is the

A

2rd most common cancer in the UK

17
Q

what type of cancer is large bowel cancer

A

adenocracinoma- polyp

18
Q

large bowel cancer risk factor

A
  • Risk factors
    • Family history
    • IBD
    • Polyposis (FAP/ HNPCC)
19
Q

large bowel cancer screening

A
  • Screening program
    • Faecal occult blood  colonoscopy
    • 60-75 yrs _ 2 years (one off at 55 years if available)
20
Q

Familial adenomatous polyposis

FAP

A
  • APC gene (tumour suppressor) mutation
21
Q

outline how FAP can cause large bowel cancer

A
  • APC gene (tumour suppressor) mutation
    1. Starts as proliferation and gross
    2. Allows cells in intestinal wall to develop polyps
    3. Polyps can leads to dysplasia and malignancy  adenocarcinoma
22
Q

presentation of large bowel cancer depends on if it is

A

right sided or left sided

23
Q
  • Right sided (ascending colon) – poor prognosis but treatable and manageable surgically
    *
A
  • Weight loss
  • Anaemia
  • Less likely to have bowel obstruction- lumen of ascending larger
  • Liquid content (site of water reabsorption)
  • Change in bowel habit is less likely
  • More advanced disease at presentation
  • Fungating –> grow out of the wall in one place (not concentrically)
24
Q
  • Left sided (descending colon)- better prognosis
A
  • Weight loss
  • Anaemia
  • Bowel obstruction
    • Narrower lumen
    • Contents more solid
  • Tenesmus
  • Early change in bowel habit
  • PR bleedings
  • Less advanced disease t presentation
  • Stenosing – concentrically make the lumen get smaller
    • Apple core abnormality(barium enema)
25
Q

small bowel cancer is

A

very rare

26
Q

red flag for small bowel cancer

A

unexplained abdo pain

27
Q

how many types of small bowel cancer

A

5

28
Q

5 small bowel cancer

A
  • Stromal (GIST)
  • Lymphoma
  • Adenocarcinoma
  • Sarcoma
  • Carcinoid (neuroendocrine)
29
Q

symptoms of small bowel cancer

A
  • Weight loss
  • Unexplained abdo pain (more common in small bowel)
  • PR bleeding
30
Q

risk factors for small bowel cancer

A
  • Risk factors
    • FAP
    • IBD
    • Coeliac
31
Q

general investigations for lower GI cancer

A
  • Endoscopy
  • Colonoscopy
32
Q
  • Staging
A
  • Staging
    • TNM staging
    • Dukes staging (for malignancy of large bowel)
33
Q

blood tests for lower GI cancer

A
  • Blood tests
    • FBC – iron deficiency anaemia
    • Tumour markers- CEA , CAL9-9
34
Q
  • Treatment for lower GI cancer
A
  • Dependent on stage and age
  • Curative = surgical intervention
  • Non-curative= Symptomatic relief= surgery to relieve blockage- stoma
  • If patient well enough- chemotherapy