L8

Question 1

homeotic transformation/homeosis?

Answer 1

one body part is transformed into another

Question 2

embryonic cuticles have ______ that are uniquely structured in each segment

Answer 2

denticle belts

Question 3

what do denticle belts do?

Answer 3

allow identification of each segments anterior / posterior identity

Question 4

all homeotic genes are homeobox genes true or false

Answer 4

false

Question 5

HX gene is involved in interacting with ____ to add _____

Answer 5

cofactor
specificity

Question 6

____ hox proteins bind the same short ____ sequence with ___ affinity

Answer 6

different
DNA
high

Question 7

gap genes do what

Answer 7

divide embryo to even more smaller and discrete regions

Question 8

initial activation of hox genes are remembered by what

Answer 8

chromatin

Question 9

polycomb group describe

Answer 9

repressive
modify histones to keep it closed and inaccessible

Question 10

trithorax group describe

Answer 10

opening up chromatin - keeps regions active

Question 11

polytene chromosomes are where in drosophila?

Answer 11

salivary glands

Question 12

what is the effect of LOF mutations in hox genes?

Answer 12

when you lose function in HOX gene, the identity of all the segments in the region where the HOX gene is expressed acquire that an anterior identity of the next most anterior sequence

Question 13

what is the effect of GOF mutation in HOX gene?

Answer 13

gene itself is the same and does the same thing but is just expressed somewhere additional it shouldn’t be

Question 14

what is posterior prevelance

Answer 14

when phenotypically, the most posteriorly expressed hox genes win

Question 15

how do you study GOF mutations

Answer 15

use heat shock promoter to express ubx gene throughout axis

Question 16

homeotic mutations identify ____

Answer 16

homeotic genes

Question 17

the hexapeptide motif is often diagnostic for _____ identity

Answer 17

hox gene

Question 18

the homeodomain of all Hox genes is highly _____ both within and between animals

Answer 18

conserved

Question 19

initial domains of homeotic gene expression are influenced by ________ and ______ genes

Answer 19

gap

pair-rule

Question 20

polycomb proteins lock-in what and how?

Answer 20

stable expression patterns
by forming inactive chromatin structures

Question 21

trithroax proteins bind ___ and alter ____ structure to give _____

Answer 21

DNA
chromatin
transcription

Question 22

_____ expression domains in anterior

Answer 22

discrete

Question 23

_____ expression domains in posterior

Answer 23

nested

Question 24

hox gene function establishes the _____ of segments

Answer 24

identity

Question 25

a GOF Antp mutation in the antennal segment converts the appendage into a _____

Answer 25

leg