L6 Flashcards
What do morphogens need to be / have?
point source
diffuse
degrade
a morphogen must diffuse ____ and degrade ____
slowly
quickly
a morphogen is …
a molecule that defines two or more cell fates at different concentrations
how can cells obtain positional information
serial signalling
which three cells in caenorhabditis elegans make the vulva?
P5p, P6p, P7p
which cells in c elegans become epidermis?
P3p, P4p, P8p
development of primary and secondary vulval fates depends upon a signal from the _____
anchor cell
_____ vulval precursor cells can respond to the anchor cell signal
all
Lin-3 is a homologue of what kind of molec?
signalling
the conc of ____ dictates the primary and secondary cell fates
Lin-3
can you express Lin-3 anywhere?
yes so long as the larvae is hot
if there is weak vs strong heat shock, what happens to lin-3
it becomes secondary + primary respectively
invagination is driven by a contraction of ____
cortical actin
the signal from the anchor cell is _____, which is detected by ____ on the vulva precursor cells
Lin-3
Let-23
Lin-3 acts as a ______
morphogen