Krebs Cycle Flashcards by Rachel Smith

Q

Other names for Krebs cycle

A

Citric acid cycle

Tricarboxylic Acid cycle

How well did you know this?

1

Not at all

2

3

4

5

Perfectly

Q

Purpose of Krebs

A

To make ATP

How well did you know this?

1

Not at all

2

3

4

5

Perfectly

Q

What molecules can enter Krebs

A

Fat
Carbs
Protein

How well did you know this?

1

Not at all

2

3

4

5

Perfectly

Q

Type of enzymes used to oxidize molecules

A

Dehydrogenases

How well did you know this?

1

Not at all

2

3

4

5

Perfectly

Q

Reduced compounds that are produced

A

NADH and FADH2

How well did you know this?

1

Not at all

2

3

4

5

Perfectly

Q

Carbs entering Krebs come from

A

Glycolysis and prep step

Acetyl CoA enters

How well did you know this?

1

Not at all

2

3

4

5

Perfectly

Q

Fats entering Krebs enter after

A

Beta oxidation

Acetyl CoA enters

How well did you know this?

1

Not at all

2

3

4

5

Perfectly

Q

Protein entering Krebs cycle

A

Each AA is unique in how it enters

How well did you know this?

1

Not at all

2

3

4

5

Perfectly

Q

Prep step of Krebs

A

Pyruvate — Acetyl CoA

How well did you know this?

1

Not at all

2

3

4

5

Perfectly

Q

Enzyme in prep step

A

Pyruvate dehydrogenase

How well did you know this?

1

Not at all

2

3

4

5

Perfectly

Q

Other compounds produced in prep step

A

Co2

NADH

How well did you know this?

1

Not at all

2

3

4

5

Perfectly

Q

Location of Prep Step

A

In mitochondrial matrix

How well did you know this?

1

Not at all

2

3

4

5

Perfectly

Q

Beta Oxidation

A

Series of rxns that produce acteyl CoA molecules

How well did you know this?

1

Not at all

2

3

4

5

Perfectly

Q

Location of beta oxidation

A

Inside mitochondrial matrix

How well did you know this?

1

Not at all

2

3

4

5

Perfectly

Q

Step 1 products and reactants

A

Acetyl CoA + oxaloacetate — citrate

How well did you know this?

1

Not at all

2

3

4

5

Perfectly

Q

Step 1 enzyme

A

Citrate synthase

How well did you know this?

1

Not at all

2

3

4

5

Perfectly

Q

Step 2 products and reactants

A

Citrate — isocitrate

How well did you know this?

1

Not at all

2

3

4

5

Perfectly

Q

Step 2 enzyme

A

Aconitase

How well did you know this?

1

Not at all

2

3

4

5

Perfectly

Q

Step 3 products and reactants

A

Isocitrate — a-Ketoglutarate

How well did you know this?

1

Not at all

2

3

4

5

Perfectly

Q

Step 3 enzyme

A

Isocitrate dehydrogenase

Q

Step 4 products and reactants

A

A-ketoglutarate — succinyl CoA

Q

Step 4 enzyme

A

A-ketoglutarate dehydrogenase complex

Q

Step 5 products and reactants

A

Succinyl CoA — succinate

Q

Step 5 enzyme

A

Succinate thiokinase

Succinate thiokinase AKA

Succinyl CoA synthetase

Step 6 products and reactants

Succinate — fumarate

Step 6 enzyme

Succinate dehydrogenase

Step 7 products and reactants

Fumarate — malate

Step 7 enzyme

Fumarase

Step 8 products and reactants

Malate — oxaloacetate

Step 8 enzyme

Malate dehydrogenase

Co2 is produced in which steps

3 | 4

NADH is produced in which steps

3 4 8

FAD is reduced during which step

6

Reaction where GTP is made

5 | Succinyl CoA — succinate

Enzymes that control rate of Krebs

Pyruvate dehydrogenase Citrate synthase Isocitrate dehydrogenase alpha KG dehydrogenase

Irreversible steps in Krebs

1, 3, 4, and prep step

Inhibitors of Pyruvate dehydrogenase complex

High NADH High Acetyl CoA High ATP PDH kinase

Activators of PDH complex

Pyruvate Ca2+ PDH phosphatase

Key rate limiting step and enzyme

4 | A-ketoglutarate dehydrogenase

Citrate synthase stimulated by

High acetyl CoA

Citrate synthase inhibited by

ATP | Low Oxaloacetate

Isocitrate dehydrogenase stimulated by

ADP | High NAD+

Isocitrate dehydrogenase inhibited by

ATP | High NADH

A-ketoglutarate dehydrogenase stimulated by

Calcium

A-ketoglutarate dehydrogenase inhibited by

ATP NADH Succinyl CoA

Prep step produces ____ NADH

1

Krebs cycle makes ____ NADH, ____ FADH2, ____ GTP

3 NADH 1 FADH2 1 GTP