Krebs Cycle Flashcards by Rachel Smith | Brainscape

Q

Other names for Krebs cycle

A

Citric acid cycle

Tricarboxylic Acid cycle

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Q

Purpose of Krebs

A

To make ATP

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Q

What molecules can enter Krebs

A

Fat
Carbs
Protein

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Q

Type of enzymes used to oxidize molecules

A

Dehydrogenases

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Q

Reduced compounds that are produced

A

NADH and FADH2

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Q

Carbs entering Krebs come from

A

Glycolysis and prep step

Acetyl CoA enters

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Q

Fats entering Krebs enter after

A

Beta oxidation

Acetyl CoA enters

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Q

Protein entering Krebs cycle

A

Each AA is unique in how it enters

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Q

Prep step of Krebs

A

Pyruvate — Acetyl CoA

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Q

Enzyme in prep step

A

Pyruvate dehydrogenase

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Q

Other compounds produced in prep step

A

Co2

NADH

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Q

Location of Prep Step

A

In mitochondrial matrix

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Q

Beta Oxidation

A

Series of rxns that produce acteyl CoA molecules

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Q

Location of beta oxidation

A

Inside mitochondrial matrix

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Q

Step 1 products and reactants

A

Acetyl CoA + oxaloacetate — citrate

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Q

Step 1 enzyme

A

Citrate synthase

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Q

Step 2 products and reactants

A

Citrate — isocitrate

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Q

Step 2 enzyme

A

Aconitase

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Q

Step 3 products and reactants

A

Isocitrate — a-Ketoglutarate

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Q

Step 3 enzyme

A

Isocitrate dehydrogenase

Q

Step 4 products and reactants

A

A-ketoglutarate — succinyl CoA

Q

Step 4 enzyme

A

A-ketoglutarate dehydrogenase complex

Q

Step 5 products and reactants

A

Succinyl CoA — succinate

Q

Step 5 enzyme

A

Succinate thiokinase

Q

Succinate thiokinase AKA

A

Succinyl CoA synthetase

Q

Step 6 products and reactants

A

Succinate — fumarate

Q

Step 6 enzyme

A

Succinate dehydrogenase

Q

Step 7 products and reactants

A

Fumarate — malate

Q

Step 7 enzyme

A

Fumarase

Q

Step 8 products and reactants

A

Malate — oxaloacetate

Q

Step 8 enzyme

A

Malate dehydrogenase

Q

Co2 is produced in which steps

A

3

4

Q

NADH is produced in which steps

A

3
4
8

Q

FAD is reduced during which step

A

6

Q

Reaction where GTP is made

A

5

Succinyl CoA — succinate

Q

Enzymes that control rate of Krebs

A

Pyruvate dehydrogenase
Citrate synthase
Isocitrate dehydrogenase
alpha KG dehydrogenase

Q

Irreversible steps in Krebs

A

1, 3, 4, and prep step

Q

Inhibitors of Pyruvate dehydrogenase complex

A

High NADH
High Acetyl CoA
High ATP
PDH kinase

Q

Activators of PDH complex

A

Pyruvate
Ca2+
PDH phosphatase

Q

Key rate limiting step and enzyme

A

4

A-ketoglutarate dehydrogenase

Q

Citrate synthase stimulated by

A

High acetyl CoA

Q

Citrate synthase inhibited by

A

ATP

Low Oxaloacetate

Q

Isocitrate dehydrogenase stimulated by

A

ADP

High NAD+

Q

Isocitrate dehydrogenase inhibited by

A

ATP

High NADH

Q

A-ketoglutarate dehydrogenase stimulated by

A

Calcium

Q

A-ketoglutarate dehydrogenase inhibited by

A

ATP
NADH
Succinyl CoA

Q

Prep step produces ____ NADH

A

1

Q

Krebs cycle makes ____ NADH, ____ FADH2, ____ GTP

A

3 NADH
1 FADH2
1 GTP