Exam 3: Nucleotides And Nucleic Acids Flashcards by Rachel Smith

Q

Committed step in purine synthesis

A

PRPP to 5 phosphoribosylamine

GPAT

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Q

Source of ribose 5 phosphate for nucleotide synthesis

A

PPP

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Q

2 time methyl donor during purine synthesis

A

THF

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Q

Nucleoside

A

Base + sugar

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Q

Nucleotide

A

Base + sugar + phosphate

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Q

Purines

A

G

A

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Q

Pyrimidines

A

T
C
U

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Q

Nucleotides made 2 ways

A

De novo synthesis

Salvage

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Q

Salvage is preferred because

A

Less ATP is needed

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Q

3 things needed for de novo synthesis

A

ATP
Ribose 5 phosphate
PRPP

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Q

___ used in both purine and pyrimidine synthesis

A

PRPP

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Q

PRPP synthetase reaction

A

Ribose 5P —> PRPP

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Q

GPAT reaction

A

PRPP —> 5 phosphoribosylamine

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Q

Steps using ATP in purine synthesis

A

3, 5, 6

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Q

Steps adding C’s in purine synthesis

A

4, 7

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Q

THF

A

Tetrahydrofolate

Q

Inadequate folate during pregnancy can cause

A

Neural tube defects

Q

___ is precursor to other purine Nucleotides

A

IMP

Q

IMP is precursor to

A

AMP
GMP
Hypoxanthine base

Q

Enzymes that use THF

A

GAR synthetase

AICAR formyltransferase
Adenylosuccinate lyase

Q

___ inhibits GPAT

A

Hypoxanthine

Q

Salvage pathway uses ____ to inhibit GPAT

A

Hypoxanthine

Q

Hypoxanthine + PRPP =

A

IMP

Q

Xanthine —> uric acid

A

Xanthine oxidase

Q

Xanthine oxidase inhibited by

A

Allopurinal

Q

Allopurinal treatment for

A

Gout

Q

Gout

A

Increase in uric acid that can accumulate in soft tissues

Q

IMP to adenylosuccinate

A

Adenylosuccinate synthetase

Q

Adenylosuccinate to AMP

A

Adenylosuccinate lyase

Q

IMP to XMP

A

IMP DH

Q

XMP to GMP

A

GMP synthetase

Q

Nucleotides degraded to

A

Nucleotides

Q

Nucleosides degraded to

A

Free bases

Q

Free bases degraded to

A

Common base (xanthine)