Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

Biochemistry II > Exam 3: Alcohol Metabolism > Flashcards

Exam 3: Alcohol Metabolism Flashcards

1
Q

Enzymes responsible for alcohol metabolism in liver

A

ADH
ALDH
MEOS
Catalase (presence of H2O2)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

If ADH becomes saturated, what ER system is used to metabolize alcohol

A

MEOS

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

Coenzyme reduced during alcohol metabolism

A

NAD —- NADH

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

Fate of acetate

A

TCA Cycle

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

Fate of NADH

A

ETC

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

Energy state in cell during alcohol metabolism

A

High

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

Metabolic pathways inhibited during alcohol metabolism

A

Gluconeogenesis
FA oxidation
Krebs
Pyruvate DH

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

What pathways would be activated under alcohol metabolism

A

Fat synthesis
Ketone synthesis
Lactate synthesis (fast glycolysis)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

During alcohol metabolism, why would glycolysis slow down?

A

High NADH levels

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

How does glycolysis regenerate NAD from NADH

A

Pyruvate —-lactate reaction

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

What would happen to blood glucose if consumed alcohol after using insulin

A

Drop in blood sugar

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

If OAA concentrations reduced and have low blood sugar, what is fate of acetyl CoA

A

Ketone formation

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

How does Disulfiram work?

What metabolite builds up?

A

Inhibits ALDH

Increase in acetaldehyde

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

How does alcohol increase urine output

A

Blocks antidiuretic hormone

More water stays in urine = larger urine volume

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

Toxic intermediate of alcohol metabolism

A

Acetaldehyde

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

Enzymes involved in alcohol conversion to acetaldehyde

A

ADH
MEOS
Catalase

17
Q

Alcoholism can lead to

A 
Fatty liver
Hepatic disease (cirrhosis)
Lactic acidosis 
Ketoacidosis 
Death
18
Q

Energy of alcohol

A

7 kcal/g

19
Q

Ethanol is absorbed where?

A

Throughout entire GI tract

20
Q

Alcohol oxidatively degraded in

A

Liver

21
Q

MEOS aka

A

Cytochrome P-450 system

22
Q

Catalase works in presence of

A

Hydrogen peroxide

23
Q

NADH is a produce when ethanol metabolized by either

A

ADH or MEOS

24
Q

Alcohol dehydrogenase pathway occurs in

A

Cytoplasm of liver cells

25
Q

MEOS is associated with the

A

ER

26
Q

Elevate NADH decreases what pathways?

A

Fat burning
Pyruvate dehydrogenase
Gluconeogenesis
Krebs

27
Q

Elevated NADH increases what pathways

A

Fatty acid synthesis
Ketone production
Lactic acid synthesis

28
Q

Lipids accumulate mostly in these tissues when ethanol metabolized

A

Liver
Myocardium
Renal tubules

Biochemistry II (13 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions