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Biochemistry II > Exam 3: Pentose Phosphate Pathway > Flashcards

Exam 3: Pentose Phosphate Pathway Flashcards

1
Q

Location

A

Cytosol

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2
Q

No ATP is __ or __

A

Produced or consumed

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3
Q

First step (glucose 6P -> 6 phosphoglucono-o-lactone)

A

Glucose 6 DH

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4
Q

Anything that consumes ___ and __ stimulates PPP

A

NADPH

Ribose

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5
Q

Oxidative phase are ___ steps

A

Irreversible

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6
Q

Oxidative Phase makes

A

2 NADPH

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7
Q

NADPH used in

A

Reductive biosynthesis
Detoxification
Respiratory burst
Antioxidant regeneration

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8
Q

Non -oxidative phase are __ steps

A

Reversible

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9
Q

Ribose 5 phosphate can be used for

A

Nucleic acids
ATP
CoA
NAD, FAD

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10
Q

Ribose 5 phosphate can be turned into ___ and ___ for glycolysis

A

Glyceraldehyde 3P

Fructose 6P

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11
Q

Using an epimerase, ribose 5 phosphate produces

A

Xylulose 5 phosphate (X5P)

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12
Q

Increase in sugar causes G6P to enter glycolysis and PPP, which increases

A

X5P

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13
Q

X5P binds ____, which dephosphorylates PFK2

A

Phosphatase 2A

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14
Q

PFK2 activates PFK1 and inhibits FBPase1, blocking

A

Gluconeogenesis

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15
Q

These 2 enzymes help transition between ribose 5P and glycolysis intermediates

A

Transketolase

Transaldolase

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16
Q

NADPH can be used to build

A

Fat
Cholesterol
Steroid hormones
Bile salts

17
Q

Detoxification makes toxins ___ by adding ___ so they can be excreted in urine

A

Water soluble

-OH

18
Q

Detoxification occurs where?

A

ER of liver

19
Q

___ system adds -OH to aromatic and aliphatic compounds for detoxification

A

Cytochrome p450 monooxygenase system

20
Q

Respiratory burst means WBC are taking in more

A

O2

21
Q

O2 + electrons =

A

Reactive molecules

22
Q

Goal of respiratory burst

A

Create harsh chemistry to kill bacteria

23
Q

Superoxide

A

O2-

24
Q

O2- —> H2O2

A

Superoxide dismutase

25
Q

H2O2

A

Hydrogen peroxide

26
Q

H2O2 —> HOCl

A

Myeloperoxidase

27
Q

HOCl

A

Hypochlorous Acid

28
Q

Antioxidant regeneration goal

A

Add election to antioxidants to keep protecting body from free radicals

“Quenching” free radicals

29
Q

ROS or RNS attack protein in ___, ___ and ___

A

Cells
DNA
Phospholipids

30
Q

O2- created by

A

ETC
Cytochrome p450
WBC

31
Q

Superoxide dismutase found

A

Everywhere

Cytoplasm
Mitochondria
ECM

32
Q

H202 —> H2O + O2

A

Catalase

33
Q

Catalase found

A

Cell peroxisomes

34
Q

H2O2 —> 2H2O

A

Glutathione peroxidase

35
Q

Glutathione peroxidase found

A

Cytosol

Mitochondria

Biochemistry II (13 decks)

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