Kidneys 101 Flashcards
3 basic functions of the kidneys?
Filtration of the blood
Regulating blood volume and blood pressure
Producing erythropoietin
The PCT reabsorbs what percentage of glucose and amino acids?
100%
The DCT is mainly involved in reabsorption of?
Sodium and calcium
What two lab values are needed to diagnose and acute kidney injury?
Cr and BUN
What are the 3 categories of renal disorders?
Prerenal
Intrarenal
Postrenal
AKI criteria?
Only need 1 of the following:
Increase in serum creatinine of >/= 0.3 above baseline within 48 hours
Serum creatinine increases >/= 50% in the past 7 days
Oliguria 6 hours
Normal Cr?
0.8-1.2 mg/dL
What is the single most valuable lab test in evaluating an AKI?
BMP
What other diagnostics are helpful for AKI?
Urinalysis, urine microscopy, measurement of urine output, renal ultrasound.
Life threatening complications of AKI?
Hyperkalemia
Fluid overload
Uremia
Metabolic acidosis
In what situations is dialysis indicated?
Serum creatinine >5-10 Unresponsive acidosis Severe electrolyte disorders Fluid overload Uremic complications
AKI is most commonly due to?
Prerenal failure
Prerenal failure is defined as?
Reduced effective blood circulating to kidney
Causes of prerenal failure?
Reduction in fluid volume(hemorrhage, dehydration)
Effective volume depletion(CHF, cirrhosis)
Impaired renal blood flow (renal artery stenosis)
What lab findings are characteristic of prerenal failure?
Serum BUN:Cr ration >20:1
Urine sodium <20meq/L
Urine specific gravity >1.020
Why is urine sodium decreased in prerenal failure?
Kidney tries to increase BP by holding on to sodium and water