ADH pathway

Question 1

Step 1

Answer 1

Stimulus: ANG II, low blood volume, increased blood osmolarity

Question 2

Step 2

Answer 2

The hypothalamus senses the above stimuli

Question 3

Step 3

Answer 3

Hypothalamus stimulates post. pituitary to release ADH into blood

Question 4

ADH binds to what effectors?

Answer 4

Hypothalamus
Kidney
Blood vessels

Question 5

Effect of ADH on hypothalamus?

Answer 5

Activate thirst center -> increases fluid intake-> increases blood volume -> increases blood pressure

Question 6

Effect of ADH on kidney?

Answer 6

increase H2O reabsorption in DCT and collecting duct -> decreases H2O lost in urine -> maintain blood volume -> decreases blood osmolarity

Question 7

Effect of ADH on blood vessels?

Answer 7

Vasoconstriction -> increases TPR -> increases BP

Question 8

Net effect of ADH?

Answer 8

Increase BP

Decrease blood osmolarity

Question 9

Feedback loop?

Answer 9

Negative feedback loop: hypothalamus and JG apparatus turn of ADH release -> turns of renin release -> turns of ANG II production