Kidney Function 3 Flashcards
Urine is always hypotonic to plasma - true or false?
False - can be hypertonic too
Where are osmoreceptors located?
In the brain
What does water deprivation lead to?
Increased extra-cellular fluid osmolarity. ADH release from posterior pituitary so water retention by kidney. Preoptic area makes you feel thirsty so you drink.
Two types of osmoreceptors: supraoptic¶ventricular nuclei (of the hypothalamus), lateral preoptic area.
What do osmoreceptors then communicate?
Release of signals then release ADH.
This molecule is 9 amino acids and secreted from the posterior pituitary.
What does excessive fluid ingestion lead to?
Decreased ECF osmolarity.
Hypothalamus - ADH release suppressed, collecting duct water impermeable, water excretion by kidney.
Lateral optical: thirst suppressed
Volume regulation:
Give details on this
Since the osmolarity of ECF is tightly controlled.
The volume of the ECF is determined by the total quantity of solute (mainly NaCl).
Regulation of ECF volume is all about sodium balance.
What does the volume of ECF contain?
Total amount of sodium in ECF.
What happens when salt concentration is increased?
Cells are more permeable to water than solutes so must take up more water rather than lose the solute.
What is plasma volume an important determinant of?
Determinant of blood pressure in veins, cardiac chambers and arteries. Low total body sodium leads to low plasma volume which leads to low cardiovascular pressures.
What is the main solute inside cells?
Potassium
What are key points about osmolarity?
- Body directly controls osmolarity and volume of ECF in vascular system.
- This affects the osmolarity and volume of the other compartments
- Normally osmolarity is maintained at expense of volume
- Osmoreceptors control water (renel excretion by controlling ADH release, intake by altering thirst)
Sodium excreted in urine = ? - ?
Why is sodium freely filtered?
Sodium filtered - sodium reabsorbed
It does not bind to proteins.
Na+ content is largely regulated by kidney by controlling what?
GFR
Sodium Reabsorption
What are the three things that GFR depends on?
1) Starlings forces
2) Hydraulic permeability
3) Surface area
Explain extrinsic control on the kidney
It maintains arterial blood pressure by controlling GFR.
Activation of sympathetic nervous system (baroreceptor response).. these nerves innovate the renal arterioles which then have a constriction.
*Vasoconstricts afferent arteriole decreases GFR. Reduces surface area of filtration barrier via mesangial cells decreases GFR.
(also increases renin release. NB: linked to (ii)regulation of sodium reabsorption slides).
Reduction in GFR will conserve sodium and water
and increase blood volume/pressure.
Explain intrinsic control of GFR - local control mechanisms within the kidney
(protects renal capillaries from hypertensive damage and maintains a healthy GFR) Autoregulation (within kidney)
Can control afferent arteriole constriction.
Mechanisms include: Myogenic response by the renal smooth muscle cells that surround arterioles. (Vasoconstriction in response to stretch when there is a sudden increase in blood pressure). Tubuloglomerular feedback by the juxtaglomerular apparatus. (Controls vasoconstriction and renin release#) #Renin linked to (ii)sodium reabsorption