Juvenile Idiopathic Arthritis Flashcards

1
Q

What is juvenile Idiopathic arthritis?

A

Group of systemic inflammatory disorders affecting children below the age of 16

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2
Q

Criteria for diagnosis of juvenile idiopathic arthritis?

A

Age of onset - <16 years
Duration of disease- >6 weeks
Presence of arthritis

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3
Q

What criteria would indicate the presence of arthritis?

A

Joint swelling or 2 of the following:
Painful or limited joint motion,
Tenderness,
Warmth

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4
Q

After 6 months what are the 3 subtypes of JIA identified?

A

Pauciarticular,
Polyarticular,
Systemic onset

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5
Q

What is pauciarticular JIA?

A

JIA of 4 or less joints

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6
Q

Age of onset of pauciarticular JIA type 1

A

Peak 1-3 years,

More common in females

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7
Q

Presentation of pauciarticular JIA type 1?

A
Limp, 
Mainly lower limb joints,
Chronic uveitis (can lead to blindness),
Irregular iris 
ANA +ve
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8
Q

Age of onset of pauciarticular JIA type 2?

A

After 8-9,

More common in boys

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9
Q

Presentation of pauciarticular JIA type 2

A
Limp,
Mainly lower limbs, 
Acute iridocyclitis 
Hip can be affected,
? Enthesitis,
? AS or spondyloarthritis,
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10
Q

Age onset and gender of pauciarticular JIA type 3?

A

Any childhood age,

Girls more common than boys

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11
Q

Presentation of pauciarticular JIA type 3?

A
Asymmetrical UL and LL arthritis, 
Dactylitis,
FH of psoriasis,
? Nail pitting,
Chronic iridocyclitis
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12
Q

What gender is more liokely to get polyarticular JIA RF -ve?

A

Female

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13
Q

Presentation of polyarticular JIA RF -ve

A
Constitutional manifestations, 
Hepato-splenomegaly, 
Mild anaemia, 
Growth abnormalities,
Arthritis of symmetric large and small joints
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14
Q

What is polyarticular JIA?

A

Arthritis of 5 or more joints

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15
Q

Age onset and gender of polyarticular JIA RF +Ve?

A

Late childhood,

Girls more common

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16
Q

Presentation of polyarticular JIA RF +ve?

A

Constitutional manifestations,
Anaemia,
Nodules,
Erosions in Xray

17
Q

Extra-articular symptoms that define systemic onset JIA?

A
Fever, 
Rash,
Lymphadenopathy,
Heptosplenomegaly, 
Abdominal pain,
Serositis,
Arthritis,
18
Q

Fever presentation of systemic onset JIA

A

Rises to 39.5C daily for at least 2 week,
Late afternoon/ evening worse,
Normal/subnormal in morning,
Fever +/- chills

19
Q

Rash presentation of systemic onset JIA

A

Evanescent salmon red eruption,
Trunk and thighs,
Fever,
+ve Koebner’s phenomenon (brought on my scratching)

20
Q

Lymph node presentation of systemic onset JIA

A

Generalised lymphadenopathy,

Non-tender

21
Q

Abdominal presentation of systemic onset JIA

A

Hepatosplenomegaly,
Abdominal pain,
+/- transaminases

22
Q

Serositis presentation of systemic onset JIA

A

Polyserositis,
Pericarditis,
Tamponade,
Myocarditis

23
Q

Pulmonary presentation of systemic onset JIA

A

Pleural effusion,

Pulmonary fibrosis

24
Q

Arthritis presentation of systemic onset JIA

A

Within 3-12 months of onset of fever,

Wrists, knees, ankles, cervical spine, hips and TMJ

25
Complications of uveitis
Posterior synechiae, Cataract, Band keratopathy
26
Treatment of uveitis?
``` Steroids, Mydriatic and cycloplegic agents, Methotrexate, Cyclosporin, Anti-TNF ```
27
1st line therapy of JIA?
NSAIDs,
28
2nd line therapy for JIA?
Methotrexate, Anti-TNF Rex, IL-1 R-antagonist (anakinra) IL-6 antagonist (toclilzumab)
29
When are systemic steroids used in JIA?
Systemic JIA, Serious disease complications, Bridge between DMARDs, Undergoing surgery
30
Risk of using systemic steroids?
Osteoporosis, Infections, Growth abnormalities
31
Surgical treatment of JIA?
Synovectomy, | Reconstructive/ joint replacement surgery
32
Growth failures that can occur in JIA?
``` Leg length discrepancies, Micrognathia, Shortening of fingers, hands, forearms, toes, feet, Short stature, Delayed puberty ```